Reuters Health - Women who begin menstruating before age 10 or after age 17 may have a higher risk of heart disease, stroke or high blood pressure than those who begin in the intervening years, according to a new study.
Menarche tends to occur earlier in obese children, so the link between earlier periods and later heart disease risk was expected, said lead author Dr. Dexter Canoy of the University of Oxford in the U.K.
But his team was surprised to find another increase in risk for older age at menarche, he told Reuters Health by email.
“Menarche, onset of first full menstrual cycle, is a marker of puberty and the onset of endocrine functions relating to reproduction, but why the timing of menarche is associated with increased vascular disease risk remains unclear,” Canoy said.
Researchers studied health data for more than one million U.K. women ages 50 to 64, including reproductive and medical history and national data on deaths and hospitalizations over the subsequent decade.
Over the course of about 11 years, almost 250,000 women were hospitalized for or died from complications of high blood pressure, 73,000 developed heart disease and more than 25,000 had suffered a stroke.
Those who had their first period at age 13, about 25 percent of the group, had the lowest risk of heart problems during the study.
Compared to those women, the four percent who reported having their first period at age 10 or younger were about 27 percent more likely to develop heart disease.
Heart disease risk increased almost as much for the one percent of women who started menstruating at age 17 or older, according to data in the journal Circulation.
Stroke and high blood pressure patterns were similar, but the increases in risk were smaller than for heart disease, the authors write.
“This is a very interesting paper confirming previous association studies showing links between early menarche and cardiovascular disease risk,” said David Dunger, a pediatric clinical scientist at the University of Cambridge in the U.K. who was not involved in the new study.
But previous studies have not included such a large group of women, he told Reuters Health by email.
The risks remained even when the authors accounted for body size, smoking and socioeconomic status, Canoy said.
These findings are likely applicable to middle-aged Caucasian women born between 1930 and 1950 in industrialized countries, Canoy said. The women in the current study were mostly white.
Researchers need to see whether the findings are similar in women of different ethnicities or from less industrialized countries, he added.
Heart disease risk was slightly different for women whose first period came at age 12 compared to those who started at age 15, but so small as to likely be clinically unimportant, he said.
“Strategies to prevent excess weight gain during childhood may also avoid menarche occurring at an earlier age than necessary, which in turn could reduce the risk of developing heart disease and stroke in the long-term,” Canoy said.
Average age at menarche has been on the decline since the late 1800s, Canoy noted.
“What is currently unexplained is whether the timing of menarche per se is somehow what is crucial or is there another factor occurring/operating at around middle-age (which might happen to be a correlate of age at menarche) that increases susceptibility to the development of heart disease,” Canoy said.
SOURCE: bit.ly/16pD4Si Circulation, online December 15, 2014.
Poster Comment:
Mr. Bill The way a woman handles her period is agood indicator if her husband will have early heart disease.19-16
[Jennifer] Mr. Bill, I'm going to try to save you some frustration. A woman's period controls her not the other way around. We know we are acting crazy, while we are doing it even, but we just can't stop. We simply have no control and we HATE it too.6-6
[Bear] Jennifer Google Chasteberry tea or supplements. It doesn't have to be like that. 2
Flwrgrl Seriously, the hormones added to milk and other dairy products have to have an effect on this. Girls with big boobs when they are 12, come on. This did NOT used to be the way it was. Add some more GMOs and other #$%$ and see what effect it has. 3-1
A K Growth hormones in animal feed is one reason children are entering puberty too early! 12-4