I review three recent papers:
Sep. 7, 2023 – Zurlo et al – The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-fetal globin genes in human erythroleukemia K562 cells
Jul. 27, 2023 – Breda et al – In vivo hematopoietic stem cell modification by mRNA delivery
Jan. 22, 2023 – Puccetti et al – Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age?
Sep. 7, 2023 – Zurlo et al – The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-fetal globin genes in human erythroleukemia K562 cells
Italian researchers treated K562 stem cells with increasing concentrations of Pfizer COVID-19 mRNA vaccine
What are K562 stem cells? – K-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research.
What are lymphoblast cells? Immature white blood cells that develop into healthy immune cells called lymphocytes. In leukemia, lymphoblasts don’t mature, instead they multiply rapidly in bone marrow and interfere with all blood cell production.
researchers were able to inhibit the growth of stem cells as Pfizer dose increased
Spike protein levels also increased with higher Pfizer mRNA doses
Spike protein increased expression of pro-inflammatory genes through up-regulation of NF-kB
Spike protein drastically decreased expression of several globin genes
Spike protein suppressed erythroid differentiation of stem cells
“The impact of SARS-CoV-2 Spike protein on cellular functions is of key interest”
“searching for circulating Spike in plasma of COVID-19 patient might help in understanding unexpected adverse effects following COVID-19 mRNA vaccination”
Conclusion: “SARS-CoV-2 S-protein, COVID-19 mRNA vaccines and SARS-CoV-2 infection might have dramatic effects of the hematopoietic compartment”
Conclusion: “need of great attention on possible alteration of hematopoietic parameters following SARS-CoV-2 infection and/or COVID-19 vaccination”