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Title: Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis.
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URL Source: http://www.ncbi.nlm.nih.gov/pubmed/9464471
Published: Sep 28, 2009
Author: Pedraza-Chaverrà J, Tapia E,
Post Date: 2009-09-28 19:12:29 by Horse
Keywords: None
Views: 68
Comments: 3
It has been reported that garlic activates nitric oxide synthase in vitro and that chronic inhibition of nitric oxide (NO) synthesis by N omega-nitro-L-arginine-methyl-ester (L-NAME) induces arterial hypertension in rats. In this work, we studied the effect of oral administration of L-NAME for 4 weeks on control and garlic-fed rats. Basal systolic blood pressure was recorded 4 weeks after garlic supplementation, and on weeks 1, 2, 3, and 4 after L-NAME treatment. At the end of the study, the in vivo NO production was evaluated indirectly by measuring the urinary excretion of the stable end products of NO metabolism, nitrite (NO2-) and nitrate (NO3-). It was found that L-NAME induced arterial hypertension on weeks 1-4 in control rats but not in garlic-fed rats, whose blood pressure remained essentially as the basal values. Also, during this time period, blood pressure remained unchanged in garlic-fed rats without L-NAME treatment. Urinary excretion of NO2-/NO3- decreased in L-NAME-treated rats, increased in garlic-fed rats, and remained unchanged in garlic-fed rats treated with L-NAME. It was concluded that garlic blocks the L-NAME-induced hypertension by antagonizing in vivo the inhibitory effect of L-NAME on NO production. PMID: 9464471 [PubMed - indexed for MEDLINE] Related articles Sodium sensitivity and sympathetic nervous system in hypertension induced by long-term nitric oxide blockade in rats. Clin Exp Pharmacol Physiol. 2000 Jan-Feb; 27(1-2):18-24. [Clin Exp Pharmacol Physiol. 2000] The effect of chronic nitric oxide synthesis inhibition on blood pressure and angiotensin II responsiveness in the pregnant rat. Am J Obstet Gynecol. 1997 May; 176(5):1069-76. [Am J Obstet Gynecol. 1997] Central and peripheral mechanisms involved in hypertension induced by chronic inhibition of nitric oxide synthase in rats. J Hypertens. 1998 Aug; 16(8):1165-73. [J Hypertens. 1998] Effect of inhibition of nitric oxide synthase on blood pressure and renal sodium handling in renal denervated rats. Braz J Med Biol Res. 2000 Mar; 33(3):347-54. [Braz J Med Biol Res. 2000] Chronic nitric oxide inhibition aggravates hypertension in erythropoietin-treated renal failure rats. Clin Exp Hypertens. 2000 Oct-Nov; 22(7-8):663-74. [Clin Exp Hypertens. 2000] » See reviews... | » See all...
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#1. To: Horse (#0)
Hypertension could be due to too much close interactions between critters. But those on smelly garlic could avoid annoying interactions as others kept their distance from them.
I hear there's strong anecdotal evidence of such hypertension in marriages of over 20 years. It doesn't even matter that the same bottle of Old Spice or lack of personal hygiene can be substituted for garlic. ;-)
It doesn't do much for systolic, and interferes with the action of vitamin E.
Redneck vs. cop: Redneck. Cop vs. n-word: Cop. n-word vs. white guilter: n-word. Being a lawyer knocks you down a peg, so redneck lawyer vs. cop and n-word lawyer vs. white guilter are toss-ups. White guilter lawyers are the lowest form of life.
#2. To: Tatarewicz (#1)
Hypertension could be due to too much close interactions between critters. But those on smelly garlic could avoid annoying interactions as others kept their distance from them.
#3. To: Horse (#0)
Open season on them.
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