I've had plenty of opportunities to try the stuff but I always took a pass. I know one guy, an eco-activist who fried his little pea brain by drinking it regularly.
Note to Drug Tourists: There are a ton of scammers claiming to be Shaman and offering "Ayahuasca Ceremonies" get references!!!
The stuff has to be made right or you will get the wrong effect and it should not be prepared in aluminum pots. You also need to take the right amount. Most tourist Shaman will give you a light dose because they don't want to deal with people freaking out, but you won't get the effects described in the video.