[Home]  [Headlines]  [Latest Articles]  [Latest Comments]  [Post]  [Sign-in]  [Mail]  [Setup]  [Help] 

Status: Not Logged In; Sign In

The death of Yu Menglong: Political scandal in China (Homo Rape & murder of Actor)

The Pacific Plate Is CRACKING: A Massive Geological Disaster Is Unfolding!

Waste Of The Day: Veterans' Hospital Equipment Is Missing

The Earth Has Been Shaken By 466,742 Earthquakes So Far In 2025

LadyX

Half of the US secret service and every gov't three letter agency wants Trump dead. Tomorrow should be a good show

1963 Chrysler Turbine

3I/ATLAS is Beginning to Reveal What it Truly Is

Deep Intel on the Damning New F-35 Report

CONFIRMED “A 757 did NOT hit the Pentagon on 9/11” says Military witnesses on the scene

NEW: Armed man detained at site of Kirk memorial: Report

$200 Silver Is "VERY ATTAINABLE In Coming Rush" Here's Why - Mike Maloney

Trump’s Project 2025 and Big Tech could put 30% of jobs at risk by 2030

Brigitte Macron is going all the way to a U.S. court to prove she’s actually a woman

China's 'Rocket Artillery 360 Mile Range 990 Pound Warhead

FED's $3.5 Billion Gold Margin Call

France Riots: Battle On Streets Of Paris Intensifies After Macron’s New Move Sparks Renewed Violence

Saudi Arabia Pakistan Defence pact agreement explained | Geopolitical Analysis

Fooling Us Badly With Psyops

The Nobel Prize That Proved Einstein Wrong

Put Castor Oil Here Before Bed – The Results After 7 Days Are Shocking

Sounds Like They're Trying to Get Ghislaine Maxwell out of Prison

Mississippi declared a public health emergency over its infant mortality rate (guess why)

Andy Ngo: ANTIFA is a terrorist organization & Trump will need a lot of help to stop them

America Is Reaching A Boiling Point

The Pandemic Of Fake Psychiatric Diagnoses

This Is How People Actually Use ChatGPT, According To New Research

Texas Man Arrested for Threatening NYC's Mamdani

Man puts down ABC's The View on air

Strong 7.8 quake hits Russia's Kamchatka


Health
See other Health Articles

Title: Slowing aging with telomerase
Source: [None]
URL Source: http://www.bbc.co.uk/news/science-environment-12207953
Published: Jan 30, 2011
Author: Neil Bowdler
Post Date: 2011-01-31 00:20:48 by Tatarewicz
Keywords: None
Views: 107
Comments: 11

Related stories

* Do we all want to live to 100? * Genes reveal 'biological ageing' * Vitamin D 'may help slow ageing'

Scientists are slowly unlocking the secrets of ageing, and some suggest treatments may soon be at hand to slow or even reverse the ageing process.

But what can science really achieve, and what are the dangers of meddling with our biological clocks?

Could such treatments induce cancers in humans, for example, and what about the world's burgeoning population and the West's "pension time bomb"? Chromosome tips

The ageing process is a complex one, and for long remained an impenetrable mystery, but progress is now being made.

Late last year, a team at the Dana-Farber Cancer Institute in Boston published a Nature paper in which they detailed the reversing of the ageing process in mice.

They targeted the chromosomes that reside within the nuclei of all cells, and specifically telomeres, caps at the tips of chromosomes. The telomeres protect the chromosomes from damage, but also shorten with age, until the cells are no longer able to replicate.

By understanding the ageing process, we can help combat arthritis, diabetes and heart disease”

End Quote Professor Tim Spector King's College London

Professor Ronald DePinho and colleagues manipulated the enzyme that regulates these tips - known as telomerase - and witnessed dramatic results. Mice engineered to lack the enzyme aged prematurely, but when the enzyme was replaced, the mice appeared to rewind the clock.

"What we were expecting was a slowing or stabilisation of the ageing process," he told the BBC. "Instead we witnessed a dramatic reversal in the signs and symptoms of ageing."

"These animals had their brains increase in size, they improved their cognition, their coat-hair was restored to a healthy sheen and their fertility was also restored."

Of course, this was a story of mice, not men, and applying such principles to humans could be an altogether bigger challenge. Telomerase has been linked with cancer, and there are likely to be many other mechanisms involved in ageing.

Many believe mitochondria may play a bigger role - genetic material contained within the cell but outside the nucleus. Mitochondria are the "power houses" of cells, but have also been seen to generate harmful chemicals linked with aging.

Then there is the role played by free radicals, highly reactive atoms or molecules that attack our bodies. Anti-ageing drug

But even though a comprehensive picture of how we age is still to be constructed, there are scientists who are already testing anti-ageing treatments on humans. Chromosome with telomeres at tips Telomeres (in red) are found at the ends of each chromosome, and shorten with age

Professor David Sinclair also works in Boston at an ageing laboratory at Harvard Medical School. He and his colleagues have been working on synthetic drugs called "Sirtuin activating compounds" or STACs.

Animal studies have indicated STACs can restore the health and life prospects of obese mice and early-stage trials in humans are now underway.

The research follows earlier work on resveratrol, a naturally-occurring ingredient of red wine. Both resveratrol and STACs appear to mimic the effects of restricting calorie intake, which has been seen to slow ageing in animals.

"This isn't going to be an excuse to eat French fries all day and watch TV but is a way to augment your healthy lifestyle and give you the ultimate benefits of perfect health which your body is capable of," Professor Sinclair told the BBC.

"It doesn't change food intake - the mice eat just normally or they get fatter, but their body doesn't seem to know they're fat and their organs and even their longevity is as good as a really healthy mouse."

But should we be experimenting with something so fundamental as ageing in the first place? And what of the ethical issues?

Professor Tim Spector of King's College London, who also works on the ageing process, says the focus is not on extending life, but on extending good health.

"If it means by living a long time you're crippled by arthritis and can't get out of the house that's not much use to anyone."

"But by understanding the ageing process, we can help combat arthritis, diabetes, heart disease, all these things which are age-related."

Professor James Goodwin, head of research at Age UK, believes access will quickly emerge as a key issue, should effective anti-ageing medical treatments be developed.

"Will everybody be able to get this technology which will give them a longer healthier life, or will it be restricted to the rich and wealthy?" he asks.

"Or how will the poorer countries regard the richer countries of the world where everyone is living well and living longer?" Œ79;

Click for Full Text!


"Will everybody be able to get this technology which will give them a longer healthier life, or will it be restricted to the rich and wealthy?" Restrict it to those who are productive enough to be of a net benefit to the community, particularly doctors, food, shelter producers.

Post Comment   Private Reply   Ignore Thread  


TopPage UpFull ThreadPage DownBottom/Latest

Begin Trace Mode for Comment # 5.

#3. To: Tatarewicz (#0)

Restrict it to those who are productive enough to be of a net benefit to the community, particularly doctors, food, shelter producers.

Naw. Any jagoff with a credit card can get it.

mirage  posted on  2011-01-31   4:22:41 ET  Reply   Untrace   Trace   Private Reply  


#4. To: mirage (#3)

Don't know if oral ingestion/digestion of "reneuve" would have much of an effect. IV administration should be be better. Nevertheless might be worth trying on some old geezer about to croak.

Tatarewicz  posted on  2011-01-31   5:17:15 ET  Reply   Untrace   Trace   Private Reply  


#5. To: Tatarewicz (#4)

I don't know if it will be effective using an oral application either, but its out there already for those with a credit card.

Its not like we can stop people from buying syringes either if that becomes the "preferred method" of delivery either.

mirage  posted on  2011-01-31   19:41:33 ET  Reply   Untrace   Trace   Private Reply  


Replies to Comment # 5.

#9. To: mirage (#5)

Could be just another snake oil scam in that the telomerase in the potion has one universal chemical structure whereas everyone's DNA which codes for this protein has slight variations in base pairs meaning that any such added telomerase could be different and subject to attack as a foreign body by one's immune system. In which case each individual would have to have telomerase synthesized from his own DNA.

Shortened telomers predispose people to early heart attacks:

http://www.springerlink.com/content/w35551tu7p626257/

Abstract Shorter telomeres have been reported in premature myocardial infarction (MI) patients. Our work aimed at confirming the association of shorter telomere with MI in two case–control studies and in familial hypercholesterolemia (FH) patients with coronary heart disease (CHD). The HIFMECH study compared 598 white male patients (<60 years) who survived a first MI and 653 age-matched controls from North and South Europe. Additionally, from the UK, 413 coronary artery bypass graft (CABG) patients and two groups of 367 and 94 FH patients, of whom 145 and 17 respectively had premature CHD, were recruited. Leukocyte telomere length (LTL) was measured using a real-time polymerase chain reaction-based method. In HIFMECH, LTL was significantly shorter in subjects from the North (7.99 kb, SD 4.51) compared to the South (8.27 kb, SD 4.14; p41;=41;0.02) and in cases (7.85 kb, SD 4.01) compared to controls (8.04 kb, SD 4.46; p41;=41;0.04). In the CABG study, LTL was significantly shorter (6.89 kb, SD 4.14) compared to the HIFMECH UK controls (7.53, SD 5.29; p41;=41;0.007). In both samples of FH patients, LTL was shorter in those with CHD (overall 8.68 kb, SD 4.65) compared to the non-CHD subjects (9.23 kb, SD 4.83; p41;=41;0.012). Apart from a consistent negative correlation with age, LTL was not associated across studies with any measured CHD risk factors. The present data confirms that subjects with CHD have shorter telomeres than controls and extends this to those with monogenic and polygenic forms of CHD.

--------------------------------------------------------------------------------

Findings make sense in that heart muscle, etc. weakens when cells run out of regenerative steam.

Tatarewicz  posted on  2011-02-01 02:43:00 ET  Reply   Untrace   Trace   Private Reply  


End Trace Mode for Comment # 5.

TopPage UpFull ThreadPage DownBottom/Latest


[Home]  [Headlines]  [Latest Articles]  [Latest Comments]  [Post]  [Sign-in]  [Mail]  [Setup]  [Help]