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Title: Taking Resveratrol for Cancer
Source: [None]
URL Source: http://boards.medscape.com/forums?1 ... N0JaTdgurC@.2a0deaef!comment=1
Published: Sep 28, 2011
Author: Cary Presant, MD, Oncology, Hematology/O
Post Date: 2011-09-28 04:14:18 by Tatarewicz
Keywords: None
Views: 54
Comments: 1

My breast cancer patient who likes taking complementary medicines, including resveratrol, sent me an email. On the internet she had found an article from 1997 which studied resveratrol in a breast cancer cell line (Proc Nat Acad Sci 1997; 94: 14138). After adding resveratrol, cell growth of one line T47D was enhanced, possibly mediated by an estrogen agonist effect. She asked, should she stop resveratrol.

Preclinical experimental evidence on resveratrol has exploded in recent years. In recent papers, overwhelmingly growth of breast cancer cell lines and transplanted tumors has been inhibited by addition of resveratrol. In addition to breast cancers, resveratrol appears to have a more generalizable antineoplastic effect. A recent study by Tyagi and coworkers (Clin Cancer Res 2011. 17; 5402) showed that in human head and neck cancer cell lines and in tumor transplants in nude mice, resveratrol produced DNA damage and apoptosis with growth inhibition (but not in DNA-repair proficient normal cells). Oral resveratrol is currently in clinical trials.

However, some data indicates that the anticancer effects of taxanes may be reduced in the presence of resveratrol (Fukui. Eur J Cancer 2010; 46: 1882). Resveratrol enhances cyclophosphamide cytotoxicity, but interactions with other drugs is not reported.

So what should I have told my patient? I told her to continue the resveratrol. By the way, I advise all my patients of the possible anticancer effects of resveratrol (as well as curcumin, green tea, soy, tomatoes, etc.) about which they will read on the internet and in news media. On days they are not receiving chemotherapy or radiation, I tell them that the complementary nutritional approaches are ok, but let me know what they are taking in the event contrary evidence becomes available. Do my patients start these? Most do on their own or to appease family members or friends who incessantly urge any beneficial diet or nutrient addition.

Examples such as this should cause all oncologists to read published papers in our medical literature to enable us to give the best evidence-based advice.

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#1. To: Tatarewicz (#0)

Soy? He recommends soy for breast cancer? It is bad for everyone, but as a phytoestrogen it is especially bad for patients with breast and prostate cancer. My goodness.

Pamela  posted on  2011-09-28   7:24:42 ET  Reply   Trace   Private Reply  

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