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Title: 'Symbiotic' Dietary Supplements Ease Chronic Constipation in Women
Source: [None]
URL Source: http://www.medscape.com/viewarticle/758008
Published: Feb 5, 2012
Author: Rob Goodier
Post Date: 2012-02-05 04:04:38 by Tatarewicz
Keywords: None
Views: 22

NEW YORK (Reuters Health) Feb 02 - "Symbiotic" dietary supplements can improve chronic constipation in women, a new study has found.

The supplements combine probiotic bacteria with fructo-oligosaccharides (FOS) in a "symbiotic" treatment that can change the composition of gut flora, researchers said last week in Orlando, Florida at the annual meeting of the American Society for Parenteral and Enteral Nutrition (ASPEN).

The number of evacuations improved significantly in the symbiotic group, Dr. Dan Waitzberg, who led the study at Hospital Santa Catarina in São Paulo, Brazil, told Reuters Health by email.

At baseline, the 100 chronically constipated women in the randomized trial averaged 0.4 bowel movements per week.

The active supplements contained Lactobacillus paracasei, L. rhamnosus, L. acidophilus, and Bifidobacterium lactis. The placebo group received maltodextrin.

By the second week, those taking symbiotic supplements had an average of 0.64 movements, while the control group had 0.47 (p=0.05).

For those taking symbiotics, the average number of bowel movements continued to increase from the second week to the fourth in the 30-day study, and the stool format and consistency improved, as well, the researchers write. At week four, the average number of movements per week was 0.67 in the treatment group and 0.42 in controls (p=0.001), according to the researchers.

They have some ideas about why the symbiotic supplements may work.

"Probably, FOS is providing a good substrate for the probiotics and butiric acid and other substances. This could improve colonic motility and stool bulk, both improving intestinal transit," Dr. Waitzberg said. "On the other hand, the probiotics may improve dysbiosis and their bad side effects by competing with pathogenic microbiota or even killing it."

The supplements were provided by SKL Pharma (S�o Paulo, Brazil). Dr. Luciana Logullo, who also worked on the study, told Reuters Health by email that the company "donated the products without any interference in the study."

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