[Home]  [Headlines]  [Latest Articles]  [Latest Comments]  [Post]  [Sign-in]  [Mail]  [Setup]  [Help] 

Status: Not Logged In; Sign In

‘Knucklehead’: Tim Walz returns to Minnesota ‘defeated'

Study Confirms the Awesome Destructive Power of Sugar in Utero Originally published via Armageddon Prose:

Ukraine mobilizing mentally challenged and deaf people lawmaker

COL. Douglas Macgregor : Trump and Netanyahu At Crossroads

.': Parisians Revolt Against Israeli Minister's Visit As Riots Grip Amsterdam

US Confirms Israel Will Face No Consequences for Not Improving Aid Situation in Gaza

Judge rules AstraZeneca, other COVID jab makers NOT immune from injury claims for breach of contract

Israel knew October 7th was going to happen

One of the World’s Richest Men is Moving to America After Trump’s Landslide Victory

Taiwan has a better voting system than America

Donald Trump on Tuesday nominated veteran, author, and Fox News host Pete Hegseth as the Secretary of Defense

"Warrior For Truth & Honesty" - Trump Names John Ratcliffe As CIA Director

"The Manhattan Project" Of Our Time: Musk And Vivek Ramaswamy To Head Department Of Government Efficiency (DOGE)

Trump, Rogan and French Fries at MsDonalds

President Trump wants a 10% cap on all credit card interest rates

Senator Ted Cruz STUNS the Entire Congress With This POWERFUL Speech (On the Border)

Kash Patel, Trump’s top choice for CIA Director, wants to immediately release classified

The £4 supplement that could slash blood pressure - reducing stroke, dementia and heart attack risk

RFK Jr. to be involved in oversight of health and agriculture departments under second Trump admin

​​​​​​​"Keep Grinding": Elon Musk's America PAC Will Continue Anti-Soros Push Ahead Of Special Elections & Midterms

Johnny B Goode

Russian Hypersonic Advances Remain Beyond Western Reach

US Preps for War vs China, Dusts-Off Deserted WWII Air Bases

Spain on high alert as deadly storms loom: new flood risks in Barcelona, Majorca, Ibiza.

U.S. Publication Foreign Policy Says NATO Knows Ukraine Is Losing The War

Red Lobster and TGI Fridays are closing. Heres whats moving in

The United Nations is again warning of imminent famine in northern Gaza.

Israeli Drone Attack Targets Aid Distribution Center in Syria

Trump's new Cabinet picks, a Homan tribute, and Lizzo's giant toddler hand [Livestream in progress]

Russia and Iran Officially Link Their National Banking Systems


Science/Tech
See other Science/Tech Articles

Title: New way to keep bacteria at bay
Source: [None]
URL Source: http://www.sciencealert.com.au/news/20120404-23282.html
Published: Apr 5, 2012
Author: staff
Post Date: 2012-04-06 05:01:41 by Tatarewicz
Keywords: None
Views: 108
Comments: 3

“By allowing bacteria to stay alive after antibiotic treatment, we believe we can also prevent the emergence of antibiotic resistance..."

New treatments that combat the growing problem of antibiotic resistance by disarming rather than killing bacteria may be on the horizon, according to a new study.

Published in Nature Structure and Molecular Biology, research led by Monash University showed a protein complex called the Translocation and Assembly Module (TAM), formed a type of molecular pump in bacteria. The TAM allows bacteria to shuttle key disease-causing molecules from inside the bacterial cell where they are made, to the outside surface, priming the bacteria for infection.

Lead author and PhD student Joel Selkrig of the Department of Biochemistry and Molecular Biology at Monash said the work paves the way for future studies to design new drugs that inhibit this process.

"The TAM was discovered in many disease-causing bacteria, from micro-organisms that cause whooping cough and meningitis, to hospital-acquired bacteria that are developing resistance to current antibiotics," Mr Selkrig said.

“It is a good antibacterial target because a drug designed to inhibit TAM function would unlikely kill bacteria, but simply deprive them of their molecular weaponry, and in doing so, disable the disease process."

“By allowing bacteria to stay alive after antibiotic treatment, we believe we can also prevent the emergence of antibiotic resistance, which is fast becoming a major problem worldwide."

The Monash team, led by Professor Trevor Lithgow from the Department of Biochemistry and Molecular Biology, showed the TAM was made of two protein parts, TamA and TamB, which function together to form a machine of molecular scale.

Together with colleagues at the University of Melbourne, they compared normal virulent bacteria to mutant strains of bacteria engineered to have no TAM.

"We noticed that proteins important for disease were missing in the outer membrane of the mutant bacteria,” Mr Selkrig said.

“The absent proteins help bacteria to adhere to our bodies and perform disease-related functions.”

Mr Selkrig said the next step for the group was to dissect the molecular mechanism of how the TAM complex functions and, in collaboration with researchers at the Monash Institute of Pharmaceutical Sciences, design an antibiotic that inhibits the TAM in bacteria.

Professor Lithgow led an international team of seven Monash researchers, and scientists from the University of Melbourne, University of Queensland, the University of Glasgow and University of Birmingham.

Post Comment   Private Reply   Ignore Thread  


TopPage UpFull ThreadPage DownBottom/Latest

#1. To: Tatarewicz (#0)

Thank you for posting all the health and financial information here.

It's appreciated.

Break the Conventions - Keep the Commandments - G.K.Chesterson

Lod  posted on  2012-04-06   9:07:24 ET  Reply   Trace   Private Reply  


#2. To: Lod, Tatarewicz (#1)

Yes, Tatarewicz always posts interesting and useful hard news here. It's one of the reasons that I check in here mornings.

Thanks, T.

A people that would and could throw the bums out in the voting booth never has to. - Prefrontal Vortex

randge  posted on  2012-04-06   9:44:00 ET  Reply   Trace   Private Reply  


#3. To: Tatarewicz (#0)

Excellent article! Good to hear that headway is being made on antibiotic resistance.

" If you cannot govern yourself, you will be governed by assholes. " Randge, Poet de Forum, 1/11/11

"Life's tough, and even tougher if you're stupid." --John Wayne

abraxas  posted on  2012-04-06   10:21:50 ET  Reply   Trace   Private Reply  


TopPage UpFull ThreadPage DownBottom/Latest


[Home]  [Headlines]  [Latest Articles]  [Latest Comments]  [Post]  [Sign-in]  [Mail]  [Setup]  [Help]