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Title: Oral Bacteria May Signal Pancreatic Cancer Risk
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URL Source: http://www.sciencedaily.com/releases/2012/09/120918121547.htm
Published: Sep 19, 2012
Author: staff
Post Date: 2012-09-19 23:49:31 by Tatarewicz
Keywords: None
Views: 119
Comments: 8
ScienceDaily (Sep. 18, 2012) — Pancreatic cancer is highly lethal and difficult to detect early. In a new study, researchers report that people who had high levels of antibodies for an infectious oral bacterium turned out to have double the risk for developing the cancer. High antibody levels for harmless oral bacteria, meanwhile, predicted a reduced pancreatic cancer risk. A new study finds significant associations between antibodies for multiple oral bacteria and the risk of pancreatic cancer, adding support for the emerging idea that the ostensibly distant medical conditions are related. The study of blood samples from more than 800 European adults, published in the journal Gut, found that high antibody levels for one of the more infectious periodontal bacterium strains of Porphyromonas gingivalis were associated with a two-fold risk for pancreatic cancer. Meanwhile, study subjects with high levels of antibodies for some kinds of harmless "commensal" oral bacteria were associated with a 45-percent lower risk of pancreatic cancer. "The relative increase in risk from smoking is not much bigger than two," said Brown University epidemiologist Dominique Michaud, the paper's corresponding author. "If this is a real effect size of two, then potential impact of this finding is really significant." Pancreatic cancer, which is difficult to detect and kills most patients within six months of diagnosis, is responsible for 40,000 deaths a year in the United States. Several researchers, including Michaud, have found previous links between periodontal disease and pancreatic cancer. The Gut paper is the first study to test whether antibodies for oral bacteria are indicators of pancreatic cancer risk and the first study to associate the immune response to commensal bacteria with pancreatic cancer risk. The physiological mechanism linking oral bacteria and pancreatic cancer remains unknown, but the study strengthens the suggestion that there is one. "This is not an established risk factor," said Michaud, who is also co-lead author with Jacques Izard, of the Forsyth Institute and Harvard University. "But I feel more confident that there is something going on. It's something we need to understand better." Izard, a microbiologist, said the importance of bacteria in cancer is growing. "The impact of immune defense against both commensals and pathogenic bacteria undeniably plays a role," he said. "We need to further investigate the importance of bacteria in pancreatic cancer beyond the associated risk." Prospective, controlled study To conduct their research, Michaud and Izard drew on medical records and preserved blood samples collected by the Imperial College-led European Prospective Investigation into Cancer and Nutrition Study, a massive dataset of more than 500,000 adults in 10 countries. Detailed health histories and blood samples are available from more than 380,000 of the participants. From that population, the researchers found 405 people who developed pancreatic cancer, but no other cancer, and who had blood samples available. The researchers also selected 416 demographically similar people who did not develop pancreatic cancer for comparison. The researchers blinded themselves to which samples came from cancer patients and which didn't during their analysis of the blood, which consisted of measuring antibody concentrations for 25 pathogenic and commensal oral bacteria. In their study design and analysis they controlled for smoking, diabetes, body mass index, and other risk factors. An important element of the study design was that date of the blood samples preceded the diagnosis of pancreatic cancer by as much as a decade, meaning that the significant difference in antibody levels were likely not a result of cancer. Instead, the underlying mechanisms that link Porphyromonas gingivalis to pancreatic cancer could be causal, Michaud said, although much more research is needed to understand this association. Meanwhile, the researchers speculate, the association of high levels of antibodies for commensal bacteria and pancreatic cancer, may indicate an innate, highly active immune response that is protective against cancer. "Genetic determinants of immune surveillance clearly play a critical role in pancreatic cancer development," the authors wrote. "Consequently, it is plausible that elevated levels of antibodies to oral bacteria in individuals serve as a marker for a genetically stronger immune response, providing protection against carcinogenesis." Michaud, who studies cancer risk factors generally, continues to investigate the association between oral bacteria and pancreatic cancer in collaboration with Izard. The National Cancer Institute was the primary funder of the study.
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#1. To: Tatarewicz (#0)
My dentist tests for oral bacteria and then allows patients to view the slide under a microscope. After several days of gargling with a colloidal silver solution, the oral bacterial count is almost nil. did your dentist recommend the colloidal silver solution or did you do it on your own?
Too much silver will turn your skin permanently blue. I sense a disturbance in the farce. Much gnashing will ensue.
It was my idea. We then discussed incorporating the Ag solution into a waterpik. They were receptive and thought it merited further study. I know several cute Hindu girls. If that occurs, I'll just tell them I'm Krishna's younger brother. I've already got the peacock feathers. ; ) Rinsing your mouth for a few minutes with a salt solution after brushing with bar soap probably would work just as well.
Baking soda perhaps. But bar soap? I believe I'll pass on that. Some environmental groups advocate "environmentally safe" products as alternatives to commercial germicides in the home-care setting. These alternatives (e.g., ammonia, baking soda, vinegar, Borax, liquid detergent) are not registered with EPA and should not be used for disinfecting because they are ineffective against S. aureus. Borax, baking soda, and detergents also are ineffective against Salmonella Typhi and E.coli; however, undiluted vinegar and ammonia are effective against S. Typhi and E.coli 53, 332, 333. Common commercial disinfectants designed for home use also are effective against selected antibiotic-resistant bacteria 53.
the quality of a man’s life is directly proportionate to
his commitment to excellence.’
#2. To: Buzzard (#1)
#3. To: Buzzard (#1)
colloidal silver solution
#4. To: christine (#2)
did your dentist recommend the colloidal silver solution or did you do it on your own?
the quality of a man’s life is directly proportionate to
his commitment to excellence.’
#5. To: Turtle (#3)
Too much silver will turn your skin permanently blue.
the quality of a man’s life is directly proportionate to
his commitment to excellence.’
#6. To: Buzzard (#1)
gargling with a colloidal silver solution, the oral bacterial count is almost nil.
#7. To: Tatarewicz (#6)
brushing with bar soap
the quality of a man’s life is directly proportionate to
his commitment to excellence.’
#8. To: Buzzard (#7)
I don't think baking soda is as effective a germicide as soap. Just rinse thoroughly after brushing and then slosh around the saline.
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