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Title: New drug being developed using compound found in red wine 'could help humans live until they are 150'
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URL Source: http://www.dailymail.co.uk/health/a ... wine-help-humans-live-150.html
Published: Mar 15, 2013
Author: By Lucy Crossley
Post Date: 2013-03-15 04:36:08 by Tatarewicz
Keywords: None
Views: 184
Comments: 8
Drugs are synthetic versions of resveratrol, found in red wine Research shows drugs which could prevent cancer and diabetes now viable Medication can be taken topically or orally Breakthrough: The new anti-aging drugs are synthetic versions of resveratrol which is found in red wine Drugs that could combat ageing and help people to live to 150-years-old may be available within five years, following landmark research. The new drugs are synthetic versions of resveratrol which is found in red wine and is believed to have an anti-ageing effect as it boosts activity of a protein called SIRT1. Pharmaceutical giant GlaxoSmithKline has been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease. The work proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans. As each of the 117 drugs tested work on the single enzyme through a common mechanism is means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer's disease and type 2 diabetes. Genetics professor David Sinclair, based at Harvard University, said: 'Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others. 'In effect, they would slow ageing.' The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed. Although research surrounding resveratrol has been going on for a decade, until now the basic science had been contested. More... Have scientists discovered reverse evolution? Study shows how house dust mites have abandoned their parasitic lifestyle to become free-living just like their ancestors Japanese scientists create 581 copies of the same mouse through 25 rounds of cloning Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer's and Parkinson's diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis. Professor Sinclair said: 'In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster.' Positive: Scientists have been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease (file picture) Positive: Scientists have been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease (file picture) The technology was sold to GlaxoSmithKline in 2008. Four thousand synthetic activators, which are 100 times as potent as a single glass of red wine, have been developed - with the best three being used in human trials. Writing in the journal Science, Professor Sinclair, who suggests the first therapeutic to be marketed will be for diabetes, said: 'Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight.' Limited trials have been carried out in people with type 2 diabetes and the skin inflammatory disease, psoriasis. Scientists found that there were benefits to the metabolism in the first group and a reduction in skin redness in the second. The drugs can be administered orally, or topically. So far, there have been no drugs developed to target ageing skin, but one major skin care range has developed a creme with resveratrol in it. Anti-aging: Drugs to target ageing skin have not yet been developed, but one major skin care range has created a creme containing resveratrol Anti-aging: Drugs to target ageing skin have not yet been developed, but one major skin care range has created a creme containing resveratrol While any drug would be strictly prescribed for certain conditions, Professor Sinclair suggests that one day, they could be taken orally as a preventative. They could therefore be used in the same way as statin drugs are commonly prescribed to prevent, instead of simply treating, cardiovascular disease. In animal models, overweight mice given synthetic resveratrol were able to run twice as far as slim mice and they lived 15 per cent longer. Professor Sinclair added: 'Now we are looking at whether there are benefits for those who are already healthy. 'Things there are also looking promising. We're finding that ageing isn't the irreversible affliction that we thought it was. 'Some of us could live to 150, but we won't get there without more research.
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#1. To: Tatarewicz (#0)
Reseveratrol is also available as a suppliment and derived from natural sources. I don't have any specific ones to recommend yet as I am still researching it but if you run a search on it Resveratrol is widely available from reputable sources. Try www.resveratrol.com as a starting place. Lots of good information. Fogie Ping. :-)
We need to follow this one closely; if they can synthesize the stuff into mega-effective dosages, what a deal. Although the living to 150 sounds like a really, really bad idea to me. I'd just like to feel good, until I don't feel anything. “The most dangerous man to any government is the man who is able to think things out... without regard to the prevailing superstitions and taboos. Almost inevitably he comes to the conclusion that the government he lives under is dishonest, insane, intolerable.” ~ H. L. Mencken Fogie Ping. :-) Lololol!!!!!! The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.
#2. To: christine, Lod, Jethro Tull, James Deffenbach, farmfriend, fogies and wannabe fogies, All, *Agriculture-Environment* (#1)
#3. To: Original_Intent, 4 (#2)
#4. To: Original_Intent (#2)
To: christine, Lod, Jethro Tull, James Deffenbach, farmfriend, fogies and wannabe fogies, All, *Agriculture-Environment*
-Alex Kurtagic
#5. To: X-15 (#4)
Do you think I was indelicate? 
#6. To: Lod (#3)
I trust Big Pharma synthetics about as far as I can throw triple trailer rig. Yes, 200 sounds much better. I like round numbers. :-) We need to follow this one closely; if they can synthesize the stuff into mega-effective dosages, what a deal.
Although the living to 150 sounds like a really, really bad idea to me.
#7. To: Lod (#3) (Edited)
Right you are, Loddy. Here's a clue from the original article: Sounds to me like the goal is to keep people alive and on their expensive (bank account sucking) medications for 80 years rather than the nominal 20 years or so. This brings into serious question quality-of-life issues. As a contractor, one of my specialties is outfitting dwellings for the needs of elderly clients, handicap accessibility etc. Getting old isn't pretty. I can't imagine the suffering caused by living well into your 100s. I plan on checking out in my 60s at the latest. Once I'm no longer to do my job, my usefulness and purpose in life will have ended. What am I going to do, lay around in pain with my carpal tunnel and multiple repetitive stress injuries watching TeeVee and crapping myself and expecting someone else to clean it up? No thanks, count me out. I'm hurting bad enough at 52 that some days I can barely carry on. Cripes, at 80 I'd be screaming in pain. The light that burns twice as bright, burns half as long...Although the living to 150 sounds like a really, really bad idea to me.
Pharmaceutical giant GlaxoSmithKline has been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease.
Godfrey Smith: Mike, I wouldn't worry. Prosperity is just around the corner.
Mike Flaherty: Yeah, it's been there a long time. I wish I knew which corner.
My Man Godfrey (1936)
#8. To: Esso, Lod (#7)
It depends upon what you do for a living I guess - and how well you take care of your body. My Grandfather retired from farming at 85 - said the 12 hour days were "getting a little long". That didn't stop him though. He still walked 5 miles a day all the way through his 90's while building 2 trawlers along the way. He checked out 20 days short of his 100th birthday from a Kidney infection not related to his age. The attending physician said it would have killed a 30 year old just as fast. He was otherwise still in good shape if a little creaky and hard of hearing. My uncle Rocky celebrated his 70th birthday by getting into a bar fight with a man half his age. Thankfully the young whippersnapper didn't suffer any permanent damage and was out of the hospital in just a few days. Rocky was still working the docks at 75 when he had a massive coronary.
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