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Title: Statins May Slow Human Aging by Protecting Against Telomere Shortening: A Feature of Senescent Cells
Source: [None]
URL Source: [None]
Published: Aug 31, 2013
Author: staff
Post Date: 2013-08-31 00:40:19 by Tatarewicz
Keywords: None
Views: 260
Comments: 28

ScienceDaily...

Aug. 29, 2013 — Not only do statins extend lives by lowering cholesterol levels and reducing the risks of cardiovascular disease, but new research in the September 2013 issue of The FASEB Journal suggests that they may extend lifespans as well. Specifically, statins may reduce the rate at which telomeres shorten, a key factor in the natural aging process. This opens the door for using statins, or derivatives of statins, as an anti-aging therapy. Share This: 76

"By telomerase activation, statins may represent a new molecular switch able to slow down senescent cells in our tissues and be able to lead healthy lifespan extension," said Giuseppe Paolisso, M.D., Ph.D., a researcher involved in the work from the Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric Medicine at Second University of Naples in Naples, Italy.

To make this discovery, Paolisso and colleagues worked with two groups of subjects. The first group was under chronic statin therapy, and the second group (control), did not use statins. When researchers measured telomerase activity in both groups, those undergoing statin treatment had higher telomerase activity in their white blood cells, which was associated with lower telomeres shortening along with aging as compared to the control group. This strongly highlights the role of telomerase activation in preventing the excessive accumulation of short telomeres.

"The great thing about statins is that they reduce risks for cardiovascular disease significantly and are generally safe for most people. The bad thing is that statins do have side effects, like muscle injury," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "But if it is confirmed that statins might actually slow aging itself -- and not just the symptoms of aging -- then statins are much more powerful drugs than we ever thought."

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Begin Trace Mode for Comment # 21.

#3. To: Tatarewicz, 4 (#0)

I just discussed this at length with my cardiologist. There are a few highly medically sound studies that support this theory. Personally, I rejected them, but to each their own. I'm not of the belief that all pharma is eeeeevil, in fact I'm glad it's available so people can make informed choices.

Jethro Tull  posted on  2013-08-31   12:21:29 ET  Reply   Untrace   Trace   Private Reply  

Having heart problems I have done a lot of reading on statins - and then chucked them all into the trash. The same result can be achieved with a change of diet supplemented with natural products such as Garlic, Tumeric, and Coconut Oil without the nasty side-effects that go along with Statins (such as damage to the Liver and Pancreas - along with the side-effects ratcat mentioned, but wait Johnny there's more!).

Original_Intent  posted on  2013-08-31   12:39:10 ET  Reply   Untrace   Trace   Private Reply  

Having heart problems I have done a lot of reading on statins - and then chucked them all into the trash. The same result can be achieved with a change of diet supplemented with natural products such as Garlic, Tumeric, and Coconut Oil without the nasty side-effects that go along with Statins (such as damage to the Liver and Pancreas - along with the side-effects ratcat mentioned, but wait Johnny there's more!).

Yep, this was my conclusion also. as of late July, my cholesterol numbers are; HDL = 37, LDL = 24, with an overall cholesterol @ 100. I'm 6'1", 200 pounds w/ a HR of 45 BPM. I run 3x a week (at least). Just effing weird that I was in the ICU with an MI this time last year :(

Jethro Tull  posted on  2013-08-31   12:56:56 ET  Reply   Untrace   Trace   Private Reply  

Yep, this was my conclusion also. as of late July, my cholesterol numbers are; HDL = 37, LDL = 24, with an overall cholesterol @ 100. I'm 6'1", 200 pounds w/ a HR of 45 BPM. I run 3x a week (at least). Just effing weird that I was in the ICU with an MI this time last year :(

Cholesterol doesn't cause heart disease, so low cholesterol will not prevent it. Inflammation of the arteries causes most heart disease. Stay away from all fried foods and any partially hydrogenated oils. Eat an onion a day it will help keep inflammation down in your arteries. High doses of niacin can also help clean your arteries out. It can also cause flushing which causes most people stop taking it, but is completely harmless.

BTW, you are in great shape, but even people in great shape cannot eat whatever they want.

RickyJ  posted on  2013-08-31   22:08:10 ET  Reply   Untrace   Trace   Private Reply  

Cholesterol doesn't cause heart disease, so low cholesterol will not prevent it

Perhaps, I simply don't know. I do know that for every medical study there seems to be a well authored alternate view. In the end we, individually, need to follow the things we were taught as kids; eat a healthy diet, exercise, limit (don't exclude) the fun food we all eat and take an 81 mg aspirin daily. I haven't a clue if this regime will extend my stay on this planet, but should I depart tomorrow it's been a great ride and I have zero regrets!

Jethro Tull  posted on  2013-09-01   10:39:18 ET  Reply   Untrace   Trace   Private Reply  

#22. To: Jethro Tull, ab, OI, 4 (#21)

Also found at the local Costco were Organic, cold-pressed, extra-virgin (I've never really understood that one), coconut oil, and organic hemp seeds.

Lod  posted on  2013-09-01 10:49:16 ET  Reply   Untrace   Trace   Private Reply  

Cholesterol doesn't cause heart disease, so low cholesterol will not prevent it

Perhaps, I simply don't know. I do know that for every medical study there seems to be a well authored alternate view. In the end we, individually, need to follow the things we were taught as kids; eat a healthy diet, exercise, limit (don't exclude) the fun food we all eat and take an 81 mg aspirin daily. I haven't a clue if this regime will extend my stay on this planet, but should I depart tomorrow it's been a great ride and I have zero regrets!

From all my reading the science supporting the Cholesterol FAD among MD's is just that - a fad - mostly resulting from Pharmaceutical Company Marketing Departments. A lot of what the MD's even know about Statins and Beta Blockers is Junk Science. When you start digging into it there is very little real scientific support for striving for abnormally low cholesterol levels.

There is even less evidence that cholesterol just spontaneously builds up. There is an underlying cause for the body's systems, which are generally a self correcting mechanism, to put down layers of cholesterol on arterial walls. Linus Pauling attributed the cause to lesions in the arterial walls as a result of subclinical Scurvy (Vitamin C deficiency). Thus the Pauling Regimen involves the use of high doses of Vitamin C along with the essential Amino Acid L-Lysine. Dr. Matthias Rath, in Clinical Study, further added the Amino Acid L-Proline as it seems to be very effective in binding with the form of sticky cholesterol, LP(a), which is what the body uses to patch the arterial lesions caused by inflammation, and break down of arterial walls (the epidermal layer for you technically minded) resulting from sub-clinical Scurvy. Your body requires cholesterol for a lot of different functions - brain health being one of the big ones. While I can't point at a study for it - the memory loss and confusion associated with Statin drugs appears, just by reasoning it out from effect back to cause, to be a result, at least in part, of the action of the drug to block cholesterol uptake - particularly in the brain. In fact I have read of a couple of studies lately the validated excessively low cholesterol as creating more problems than it allegedly solves. There is a good body of clinical, and anecdotal, evidence that strongly supports the preceding contention. However, Statins are a big money machine for Big Pharma (who pays for all of those Bermuda Vacations for high level FDA administrators and "researchers") and anything which invalidates the need for that particular "Cash Cow" will be fought tooth and nail. After all is said and done Big Pharma, and by extension the FDA, is not about health but about making money.

However, I am NOT an MD and this is in no way medical advice. (Boilerplate disclaimer since the FDA Gestapo frowns on anything not approved of by their bosses at Big Pharma - the foul endemic corruption at the FDA being what it is.)

Original_Intent  posted on  2013-09-01 14:31:17 ET  Reply   Untrace   Trace   Private Reply  

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