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Health
See other Health Articles

Title: Officials Scramble to Import Emergency Meningitis Vaccine, Halt Outbreak at Princeton
Source: [None]
URL Source: [None]
Published: Nov 16, 2013
Author: An Phung |
Post Date: 2013-11-16 02:10:37 by Tatarewicz
Keywords: None
Views: 68
Comments: 3

NBC The emergency vaccines, which have not been approved for use in the U.S., would be used to help stop an outbreak of Type B meningitis.

Emergency doses of a meningitis vaccine may be on their way to Princeton University in an effort to halt an outbreak that has infected seven students there this year, even though the drug isn't approved for use in the United States.

Health officials said on Friday that they will import Bexsero, a vaccine approved only in Europe and Australia, but not in the U.S., that protects against meningitis B, NBC News reported.

Related Stories "This is a bad disease, and we know how devastating it is," Dr. Thomas Clark, acting head of the Centers for Disease Control's meningitis and vaccine preventable diseases branch, told NBC News. "A lot of us had a gut feeling that there would be more cases and we should get the ball rolling."

As many as 8,000 undergraduate and graduate students at the Ivy League school could be inoculated to stymie the spread of the illness, which is a dangerous infection of the protective membrane that covers the brain and spinal cord. The infection kills 10 percent of teens and young adults who get it, according to NBC News.

The university has been working with CDC officials to stop the spread of the disease. In October, the CDC submitted an investigational new drug application, or IND, to have the vaccine imported after a fifth student fell ill. Since then, two more students have been diagnosed. The latest case was uncovered on Sunday.

The drug will be approved for use in Princeton community only because of the seriousness of the outbreak, Clark told NBC News. Clark said the vaccine is regarded as safe, and the IND does not imply that it's an experimental vaccine.

Three of the cases involved students living in campus dorms, according to NJ.com. Six of the infected students have recovered from the illness. The seventh student is recovering.

In September, the school distributed red cups with the message "Mine. Not Yours" to encourage students to not share their drinks as a way to curb the spread of meningitis, which is spread from person to person by contact, kissing or coughing.

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#1. To: Tatarewicz (#0)

As many as 8,000 undergraduate and graduate students at the Ivy League school could be inoculated to stymie the spread of the illness, which is a dangerous infection of the protective membrane that covers the brain and spinal cord.

Nice test group for a new vaccine that purports to protect the brain.

I'm sure it was happenstance that Princeton had some bad cases of meningitis that prompted the use of this untested vaccine.

scrapper2  posted on  2013-11-16   2:15:56 ET  Reply   Trace   Private Reply  


#2. To: scrapper2 (#1)

Seems to have been tested in Europe where testing is just as rigorus as in US if not more so.

Tatarewicz  posted on  2013-11-16   4:19:20 ET  Reply   Trace   Private Reply  


#3. To: Tatarewicz (#2)

a. The UK rejected it this summer.

www.fiercevaccines.com/st...s-vaccine-unit/2013-07-25

snip

After considering two cost-effectiveness analyses--one independent, one from Novartis--JCVI concluded Bexsero is highly unlikely to meet U.K. value criteria at any price. JCVI also noted that antibody responses from Bexsero wane rapidly and its efficacy against disease is yet to be established. If Novartis is to overturn the decision, it must allay some of the concerns expressed by JCVI. "We need to know how well it will protect, how long it will protect and if it will stop the bacteria from spreading from person to person," Department of Health immunization director David Salisbury said.

b. Epidimiologists have tracked the geographical distribution of bacterial N. meningitidis serogroups, 5 of which cause 90% of the outbreaks (A, B, C, Y, and W-135). In the USA, the most common serogroup risk is for serogroup Y @ 37% whereas B is 32%. (Europe's rate is far higher for B. Ditto for Canada and Argentina and Taiwan.)

Yet 7 Princeton students were infected with serogroup B. Go figure.

www.meningitisinfo.com/Epidemiology_ssi.aspx

scrapper2  posted on  2013-11-16   14:46:31 ET  Reply   Trace   Private Reply  


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