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Health See other Health Articles Title: Wrong About Alzheimer’s All Along Yahoo... If Claude Wischik is right, almost 20 years of drug development for Alzheimer’s disease have been a costly mistake. Wischik, a chair in mental health at the University of Aberdeen in Aberdeen, Scotland, is a founder of TauRx, a Singapore-based pharmaceutical company. He’s also one of several scientists loudly questioning the focus of most Alzheimer’s research. Dominating the research field is a protein called beta amyloid, identified by Alois Alzheimer in 1906. Most researchers believe Alzheimer’s disease to be the caused by the accumulation of beta amyloid in the brain. Beta amyloid is sticky and forms plaque, which then strangles healthy cells, according to the amyloid theory of Alzheimer’s disease development. More than 100 drugs targeting beta amyloid have failed. Perhaps the drugs weren’t good, or perhaps the drugs were administered too late to be helpful. Or, if Wischik is right, beta amyloid has been the wrong focus all along. READ MORE E-Cigs Can Poison Kids “It’s extraordinary that in the face of these failed trials, the claims for amyloid remain exactly the same as though there haven’t been any failure,” Wischik said. “There’s been no fundamental revision of the thinking.” Five million Americans age 65 and older currently have Alzheimer’s disease, according to advocacy organization the Alzheimer’s Association. That number is expected to rise to 16 million in 2050. Because dementia results in the gradual loss of capabilities, Alzheimer’s patients require more-expensive care than others on Medicare and Medicaid, totaling $150 billion a year in the U.S. READ MORE The Danger of “Natural” Medicine There is no cure for Alzheimer’s disease, and early diagnostic tests are still controversial. Pharmaceutical company Eli Lilly & Co. developed an imaging agent called Amyvid, which binds to beta amyloid in the brain. It’s a radioactive compound, which means it can be used with MRI machines to determine the amount of beta amyloid in the brain. To determine if beta amyloid-targeted drugs are failing because they’re administered too late, it will be key to find patients who carry a lot of beta amyloid in the brain but haven’t yet had any symptomatic behaviors. Though the U.S. Food and Drug Administration has approved the $3,000 test, Medicare and Medicaid will only reimburse its use in clinical trials. READ MORE Broken Hearts Can Kill You Led by Risesa Sperling, researchers at Harvard Medical School will recruit about 1,000 people whose brains show amyloid pathology, and are testing Lilly’s antibody treatment for Alzheimer’s, called solanezumab, for three years. The study is unique because the people recruited won’t have symptoms of dementia when the trial starts. It is the first such trial in late-onset Alzheimer’s disease, and if it fails, it may strike another blow to the amyloid hypothesis. The drug already failed to show any efficacy in two late-stage clinical trials for patients with mild to moderate Alzheimer’s disease. If it fails to protect patients at earlier stages in the disease, it could herald the end of amyloid’s dominance in the field. (It’s worth noting that less than 1 percent of Alzheimer’s patients are early-onset patients. Drugs that help them may not aid late-onset patients.) Wischik isn’t alone in his amyloid skepticism, either. Mike Williams, editor of the Journal of Biophysiology, says there’s “no evidence” amyloid is causative. READ MORE Should Circumcision Be Mandatory? “Amyloid, despite 30 years of research, really hasn’t gotten anywhere,” Williams said. “We’re going to see some major changes if the amyloid hypothesis is totally and utterly wrong.’’ Wischik proposes another mechanism. Beta amyloid, he thinks, is one of many things that can stress cellular garbage disposal in the brain. One of these things is tau, another protein used in cells to hold open channels so they can receive nutrients. When tau misbehaves, it clumps together, and the cells can’t get the food they need. What’s more, once the tau’s gone bad in one area of the brain, there’s a runaway chain reaction in the brain. Slowly, more and more of the tau goes bad, until a patient has Alzheimer’s disease. READ MORE Anti-Anxiety Meds Are Killing You In the 1990s, researchers (including Wischik) showed that in human beings, the degeneration of tau tied more directly to the loss of mental capacity than beta amyloid. Though tau is promising, it’s hard to get funding for researching it, because many of the scientists making grant decisions are what Wischik calls “members of the Church of the Amyloid.” Wischik’s TauRx is putting his money where his mouth is. A compound called TRX-015, targeting sickness-generating type of tau, has enrolled about 900 of more than 1,500 patients in a study. It’s in the last of three phases of clinical study typically required for regulatory approval, and will last fifteen months. Data from the trial will likely appear in the first half of 2016. READ MORE Autism’s Unsettling New Normal Results from a previous study, conducted in 321 people in the UK and Singapore, showed that patients on the study drug, then called Rember, scored 5.5 points better on a 70-point scale cognitive test than those who took placebo. The group who took the study drug didn’t decline in function for more than a year. The most common side effects were diarrhea and discolored urine. Though that study was presented at the scientific meeting of the International Congress on Alzheimer’s and Dementia in 2008, it hasn’t yet been published in a peer-reviewed journal, said Williams. That means that the results should be viewed skeptically, he said. If TRX-015 doesn’t work, Williams said, there are other approaches to take in the disease, such as limiting inflammation or looking at how mitochondria, the energy storehouses of a cell, go rogue during the course of the disease. READ MORE Oil Pulling: Miracle or Mess? “We’ve still got so many other findings in the wings,” Williams said. “If any of these got prioritized and funded to the extent of amyloid, we might be a lot closer to getting a drug than we are now.” Related from The Daily Beast Poster Comment: [The Captain] This article sounds so much like what's happened in the cancer "industry". It's become so disjointed and trillions of dollars have been raised and squandered. Many promising therapies have been completely overlooked because the drug companies want to have the "magic pill" that they can patent. Meanwhile, thousands of people die from archaic chemotherapy, surgery, and radiation, and at the same time, the Gerson Clinic cures hundreds of people each year (mainly from proper nutrition) who otherwise would have died FROM conventional treatments. The US diseasecare system is so corrupt I'm surprised anyone stays in this country for treatments. And to boot, there is still very little attention paid to PREVENTION-that could PREVENT about 75-95% of these dreadful lifestyle diseases! Our government should require more money to be spent on prevention and health promotion rather then the measely 1% of every dollar spent on "healthcare".+12-4 [Darbee] Gerson therapy is basically a vegetarian diet, coffee enemas, loads of fresh juices and supplements. I do not believe that it can cure cancer, but a vegetarian diet certainly won't hurt you and may help you to heal from the effects of cancer surgery and other medical treatments. On the other hand, high amounts of antioxidants that are consumed when a person already has cancer has been shown to accelerate cancer growth, so all those juices with their abundance of antioxidants might not be a good idea. As for prevention, it's a good idea to eat a whole foods diet, and I am a vegan so I certainly agree with preventative lifestyles, but prevention will never stop cancer because there is a strong genetic component to it. Babies are sometimes BORN with cancer, and of course small children also get it. I wish there was a cure for all cancer and nobody would ever die of it again, but there isn't. I don't think it's a conspiracy either. People all over the world are trying to cure cancer and many devote their entire lives to finding a cure. We just aren't smart enough to defeat it yet. [RARE EARTH] My mother is stage 8 Alzheimers and knows nobody anymore. The genetic link is there. Her mother, whom nobody diagnosed as having Alzheimers, died years ago without knowing anybody. It concerns me greatly as being in my 50's, am I to travel down the same path? that said, I am excited about new techniques that are appearing, I work with one, but in a different field of study. Interference RNA, likely holds great promise for unlocking this disease. Using this technique, production of the rogue protein/s can simply be turned off. However technical problems remain. Our cells are very resistant to uptake of RNAi, a way that works for some insects such as using a hairpin double stranded RNA won't work for us, because our digestive system is full of nucleases that simply tear it apart. Not sure if it could be simply injected, but I suspect not because there are scientists looking at this. it may take partnering it with a virus to get delivery. But I do have hope for the future of this and other genetic based diseases.+8-3 I forgot about including the stem cell research too. Neurostem (CUR) is working with a stem cell therapy for a number of neurological diseases including Alzheimers. They are having great results for treatment of Amylotrophic Lateral Sclerosis, Lou Gherig's disease and are in Stage 2 Clinical trials now. The Alzheimers work isn't as far along, but the technique should be able to provide some relief there too. Not likely a cure, but could possibly maintain cognative abilities far longer than what is currently available. Take the time to look the company up and read up on their work.+2 [Sparky Zoner] Both very promising scientific methods that are some years away. RNAi delivery is THE issue. Also keep in mind that producing too much the protein from the target gene must be the basis for the disease. Some diseases are caused by not producing enough of the protein which prevents use of an RNAi strategy. Virus delivery by it's very nature may be the answer in gene therapy approaches but controlling the insertion of the gene in the right cell, at the right level and the right time are beyond consideration for most disease. Monogenic diseases stand the best chance at this point. +1 American Patriot From my own research on my dissertation, an insufficient amount of niacinamide leads to the break down of tau. You can get it at any drug store or health food shop. Just saying - why die of a curable disease that only costs pennies of day to cure and prevent? +4 [JoelMcDokes] Have ever thought why does the research on this or any other illness always come down to we need more research. Answer we need more money. Big pharmacy companies are controlling how and when research is done, why, they have these drugs that are useless and want to get as much as they can before going on to another that they already have. Its a money game. I read all the time about how we are on the verge of knowing how to treat a disease but we need more time and money. If a cure was found and used the people that have jobs of finding the cure would be out of work. Figure it out for yourselves.+6-4 [D'Artagnan] It thier pharamacy company. Not yours and not the governements. It called fee enterprize. Without pharacy companies reserch and development of drugs for cures, only the fittest would surrive, numbnuts. [JoelMcDokes] You should learn how to compose a sentence before you post and then call someone numbnuts.I could call you and idiot but that wouldn't be very nice now would it. [JosephS] Loved one with Alzheimer's? Look into using Ibuprofen and nicotine patches. I'm not kidding. It really can help and give people a lot more time. Doc's won't order it or even think about it because these drugs are relatively cheap.+1-1 [Jibbie] Jack LaLanne lived to be a healthy 96, doing exercise 2 hours each morning and not eating sugar. I think he was on to what works. Richard Bernstein M.D. who wrote "The Diabetes Solution" and has had Type 1 diabetes since he was 12, but is now a healthy 78, certainly believes that our high sugar diet is a reason for our health issues. I got his book at the library and found his lectures on YouTube to be very helpful. He treats mostly Type 2 diabetics in his practice as we have 26 million in America. +5-4 [Allen] A few weeks ago, a European Medical Journal discovered that the majority of AD patents had fungus in their bloodstream. Certain fungi make poisonous byproducts called mycotoxins and several of those are neurotoxic. AD patients craving carbs are feeding their fungi as they parasitize man. Just saying... +4-2 [Leaning Forward] I am not in the medical field. Through the years, I have always thought that whatever causes arthritis is causing Alzheimer. That which restricts the flow of blood to the nerves in our tendons (causing pain in our joints) is also restricting the flow of blood to the tissue in the brain. +1-2 Oliver...Alzheimer's is most likely stem from individual life style. My regiment is somewhat controversial but it works. I'm a sole believer in belief that maintaining active minds by constantly adding new information by reading printed materials, visual, etc.; using acquired information's; attend nutrient and business seminars; interaction with man and machine for motor skill and esteem development; physical activities sweat like a horse at least one day a week; eat proper nutritional foods; daily bowel movement must have fiber for bulk; consume quality multivitamins, B Complexes, antioxidants and maybe some others; avoid any type of prescription drugs; avoid dependency on medical care for cure too late and prevention is pristine; stress management and by mastering the skill prioritizing own activities and be in charge when possible; learn to delegate task by trusting other's integrity; get the hell off your jack #$%$; Keep away from fructose laced foods and processed foods, go to basic; dispose body toxin by sweating, urination by much water consumption, bowl movements for disposing of body toxin and minimizing of recycling of bile's; toxin free environment is safe way for health you want, understand the meaning of epigenetics and stop the anxiety, that's stress for tau feeding your brains, establish a hobby. I'm 73 and wife 78, we travel enough for whatever, driving to Alaska in two months, children are #$%$ured we are both financially and sound health, they can focus on their own need. Last and not least, focus on the benefits and become the solution source rather than best trouble shooter in town.+1-13 Post Comment Private Reply Ignore Thread Top • Page Up • Full Thread • Page Down • Bottom/Latest Begin Trace Mode for Comment # 6.
#1. To: Tatarewicz (#0)
http://www.bbc.co.uk/news/health-11035500 Rheumatoid arthritis protects against Alzheimers
Many cases of arthritis/rheumatism are caused by food allergies. If I eat oats, I get a severe case of back spasms and pain, which feels like bone grating on bone. I cannot eat grains at all, except rice and millet. Even Bob's Red Mill Gluten-free corn bread mix cripples me. There are so many different theories on Altzheimers. I'm inclined to lean toward the fatty acid/omega 3-9 theory which states that we are getting too high a proportion of bad GM oils (omega 9s). My hubby's father had Altzheimers and he has had occasional symptoms of it. But once he gets on coconut oil and Acetyl L Carnitine, he improves to normal. I think that phosphatidyl-choline is also important. So it is (good) oils and oil absorption into the body which is critical. We only use olive oil for salads and coconut oil for cooking. I also wonder about plastics (BPA) in the food supply. We have mostly eliminated the plastics but we do eat some canned goods in the winter which sometimes are lined cans. So I'm leaning toward these two issues as being the causative factor. We grow most of our own food and I cook most everything from scratch but we do eat out one or twice a week. We usually eat from the salad bar but those salad oils still contain GM oils.
My elementary knowledge of chemistry/genetics tells me GMOing of plants should not affect the structure of oils as carbon-hydrogen structures. It's when you get into amino acid clusters and nucleotides that you might have incompatible variations. Perhaps we should insist that processors include a diagram of the structure of their edible oils on containers.
The problem with the GMO corn/canola/soy oils is that they are engineered to produce their own pesticides which is carried in trace amounts into the digestive tract, killing and modifying our digestive tract flora and ability to digest food properly. This is leading to a huge epidemic of Celliac disease, leaky gut syndrome and food allergies. And these oils are all omega 6 and 9, while the natural oils (olive oil, etc) are omega 3. Our digestive tracts cannot handle the high proportion of hydrogenated omega 9 oils. These synthetic oils have caused an epidemic of overweight people. Switching to coconut oil causes immediate weight loss of the consumer.
If there are chemical pesticides in GMO or any other oils we have to ask our legislators why they're not listed among ingredients?
http://articles.mercola.com/sites/articles/archive/2014/04/15/glyphosate-health- effects.aspx? e_cid=20140415Z1_DNL_art_2&utm_source=dnl&utm_medium=email&utm_content=art2&utm_ campaign=20140415Z1&et_cid=DM44441&et_rid=488832812 Gut-Wrenching New Studies Reveal the Insidious Effects of Glyphosate (RoundUp) April 15, 2014 | By Dr. Mercola Increasing exposure to glyphosate, the active ingredient in Monsanto’s Roundup herbicide, may be at least partially to blame for rising rates of numerous chronic diseases in Westernized societies, according to recent research. The finding, published in Entropy,1 has ramifications for virtually every man, woman and child in developed nations, as this pesticide is widely used on both conventional and, especially, genetically modified (GM) crops (to the tune of more than one billion pounds sprayed in the US alone). If you eat processed foods, most of which are made with GM corn and soy ingredients, you’re consuming glyphosate residues, probably in each and every bite. Knowing this, and the fact that tests show people in 18 countries across Europe already have glyphosate in their bodies,2 the following news should leave you very, very concerned… if not compelled to take action against this health-endangering chemical. Glyphosate May Be a Key Factor in the Development of Chronic Disease While Monsanto insists that Roundup is safe, a peer-reviewed report authored by Anthony Samsel, a retired science consultant, and a long time contributor to the Mercola.com Vital Votes Forum, and Dr. Stephanie Seneff, a research scientist at the Massachusetts Institute of Technology (MIT), reveals how glyphosate wrecks human health. They argue that glyphosate residues, found in most commonly consumed foods in the Western diet courtesy of GM sugar, corn, soy, and wheat, “enhance the damaging effects of other food-borne chemical residues and toxins in the environment to disrupt normal body functions and induce disease.” Interestingly, your gut bacteria are a key component of glyphosate’s primary mechanism of harm. -- You may be wondering why, if GM foods are so potentially toxic, Americans aren’t dropping like flies. Well, this is a debatable statement, as with rates of chronic diseases climbing exponentially, many Americans are dying before their time. Furthermore, rats only live a few years, which is why you’re able to see tumors develop rapidly in response to dietary changes. Humans live around 80 years, so we will notice these effects in animals long before we see them in humans. The gigantic human lab experiment of eating GM foods is only about 10 years old, so we are likely decades away from tabulating the human casualties. As discussed above, glyphosate contamination is but one route by which GM foods are poisonous. It has a number of devastating biological effects. So much so that it may very well be one of the most important factors in the development of a wide variety of modern diseases and conditions. In summary, these detrimental effects include: -Nutritional deficiencies, as glyphosate immobilizes certain nutrients and alters the nutritional composition of the treated crop -Disruption of the biosynthesis of aromatic amino acids (these are essential amino acids not produced in your body that must be supplied via your diet) -Increased toxin exposure (this includes high levels of glyphosate and formaldehyde in the food itself) -Impairment of sulfate transport and sulfur metabolism; sulfate deficiency -Systemic toxicity—a side effect of extreme disruption of microbial function throughout your body; beneficial microbes in particular, allowing for overgrowth of pathogens -Gut dysbiosis (imbalances in gut bacteria, inflammation, leaky gut, and food allergies such as gluten intolerance) -Enhancement of damaging effects of other food-borne chemical residues and environmental toxins as a result of glyphosate shutting down the function of detoxifying enzymes -Creation of ammonia (a byproduct created when certain microbes break down glyphosate), which can lead to brain inflammation associated with autism and Alzheimer’s disease
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