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Health See other Health Articles Title: Curcumin: King of Anti-Inflammatories Curcumin: King of Anti-Inflammatories Tuesday, 03 Jun 2014 04:30 PM By Dr. Blaylock The latest research convincingly suggests that most disorders of the brain are the result of prolonged inflammation. Usually, brain disorders result from low-grade smoldering inflammation. The inflammation can have many sources, including viral infections, inhaling exhaust fumes, toxic metals (mercury, lead, cadmium, manganese, iron, copper), minor strokes, autoimmune diseases, food allergies, and brain injury. Inflammation in the brain is triggered by a very complex series of reactions within brain cells. When the brain becomes inflamed, specialized immune cells called microglia secrete toxic chemicals including free radicals, lipid peroxidation products, excitotoxins, and immune messengers called cytokines. These caustic chemicals slowly damage critical areas of the brain, destroying synapses (the connectors between brain cells) and dendrites (the branched ends of brain cells that transmit signals in the brain). Eventually these chemicals lead to the death of brain cells, or neurons, themselves. The neurological disorder that develops with inflammation depends on the areas of the brain most affected. For example, in Parkinson’s disease it is the midbrain (substantia nigra and striatum). In Alzheimer’s disease, it is the hippocampus, frontal lobes, parietal lobes, and discrete areas of the brain stem that are most affected. Yet in all of these age-related, neurodegenerative disorders we see common changes, including: • High levels of microglial activation • Evidence of excitotoxicity • Free radical damage • Accumulation of oxidized lipids and proteins • Elevated levels of pro-inflammatory cytokines The hallmark of Alzheimer’s disease is the accumulation of nasty-looking microscopic substance called amyloid plaque. In the past, it was thought that a special form of amyloid plaque, called fibrillated amyloid, was the culprit. Now we have learned that a special form called amyloid oligomers is most toxic to the brain. These oligomers act like caustic balls of goo, slowly burning neurons and connections around them. The brain reacts by activating microglia (its immune cells) in the hope of removing the oligomers. Instead, the immune cells become the problem. They begin to secrete caustic chemicals of their own — mainly inflammatory immune chemicals and excitotoxins (glutamate, aspartate, and quinolinic acid). We call this process immunoexcitotoxicity. Immunoexcitotoxicity also occurs with head injuries, strokes, exposure to brain-toxic metals, certain pesticides/herbicides, and brain infections. It is a universal reaction when the brain is disturbed. Curcumin has shown itself to be the king of anti-inflammatory substances, equal to the most powerful pharmaceutical drug. Curcumin is a flavonoid (an organic compound) extracted from the spice turmeric. It is the curcumin that gives the spice its bright yellow color. Turmeric, a native plant of Asia, is in the family of plants called Zingiberacae, and is a relative of ginger. The spice turmeric contains a number of compounds, but the most important are the curcuminoids: curcumin, demethyoxycurcumin, and bisdemethoxycurcumin. Curcumin is the principle flavonoid in turmeric, making up 2 to 5 percent of the plant. Turmeric is a staple of the Indian diet. Not surprisingly, colon cancer rates in India are a fraction of those in the West, and Alzheimer’s disease is one-quarter as prevalent. Because Indians mix turmeric with fatty foods, it is absorbed very well. Read Latest Breaking News from http://Newsmax.com www.newsmaxhealth.com/Dr-...3/id/574921#ixzz33ySMT9JF Poster Comment: The meningitis I suffered from is much more virulent in regards to memory loss. I have been getting some of it back, albeit, very slowly. The most revealing part of this article: The hallmark of Alzheimer’s disease is the accumulation of nasty-looking microscopic substance called amyloid plaque. In the past, it was thought that a special form of amyloid plaque, called fibrillated amyloid, was the culprit. Now we have learned that a special form called amyloid oligomers is most toxic to the brain. These oligomers act like caustic balls of goo, slowly burning neurons and connections around them. The brain reacts by activating microglia (its immune cells) in the hope of removing the oligomers. Instead, the immune cells become the problem. They begin to secrete caustic chemicals of their own — mainly inflammatory immune chemicals and excitotoxins (glutamate, aspartate, and quinolinic acid). We call this process immunoexcitotoxicity. Immunoexcitotoxicity also occurs with head injuries, strokes, exposure to brain-toxic metals, certain pesticides/herbicides, and brain infections. It is a universal reaction when the brain is disturbed. Post Comment Private Reply Ignore Thread Top • Page Up • Full Thread • Page Down • Bottom/Latest
#1. To: BTP Holdings (#0)
Thank god it didn't erase all those cool concert security gigs you experienced, eh?
Support bacteria. (The world needs more culture)
Immunoexcitotoxicity also occurs with head injuries, strokes, exposure to brain-toxic metals, certain pesticides/herbicides, and brain infections. Thank god it didn't erase all those cool concert security gigs you experienced, eh? Excitotoxins are found in foods such as Ramen Noodles. This is bad stuff, and I know a guy at work that eats that junk frequently. Not only that, I was just in the local restaurant, and was telling a waitress about working Dokken in Chicago at the Vic Theater. I was doing the after show party, and there were two guys there that were Dokken freaks. I was looking after one of them, and I looked over and the other one had Dokken pinned up against the wall. He was looking over at me, and mouthing the word, "Help". So, I got bot5h of them out of there. Then, there was this girl leaning up against the pillar. Dokken picked up her top and signed across her hooters. I bet she didn't take a shower for a week. I got them all on the bus after that, and the driver closed the door. Dokken came up front and had the driver open the door. He came off the bus, shook my hand and thanked me personally. That was really nice of him. He also told me, "Get some sleep." LOL;) "When bad men combine, the good must associate; else they will fall, one by one." Edmund Burke
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