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Health See other Health Articles Title: Time to Rethink the Way We Think About Saturated Fatty Acids, Researchers Say NEW YORK (Reuters Health) - Not all saturated fatty acids are alike. New research show that different SFAs have opposing effects on type 2 diabetes. Even-chain SFAs are associated with a higher risk of type 2 diabetes whereas odd-chain SFAs and longer-chain SFAs are tied to a lower risk of the disease, the researchers found. "Our results indicate that different SFAs have differential associations with metabolic risk. Therefore, to classify all SFAs as having adverse health effects, as has conventionally been done, does not acknowledge their potentially heterogeneous associations," conclude Dr. Nita Forouhi from the University of Cambridge in the UK and colleagues in the Lancet Diabetes & Endocrinology, online August 6. Dr. Dariush Mozaffarian, dean of the Friedman School of Nutrition and Policy at Tufts University in Boston and author of a comment published with the paper, agrees. "We need to move away from unhelpful classifications and policies based on crude groupings of merely chemically related nutrients (eg, total saturated fat) and their predicted or postulated effects on risk -- which, in addition to scientific dubiousness, create confusion for consumers and opportunities for manipulation by industry -- and towards food-based guidelines that mainly consider prospective evidence for effects on clinical endpoints," he writes. Dr. Forouhi and colleagues used the EPIC-InterAct study to assess associations between individual plasma phospholipid SFAs and new-onset type 2 diabetes. The cohort included 12,403 cases of type 2 diabetes from eight European countries. After accounting for other risk factors, measured even-chain SFAs (myristic acid, palmitic acid, and stearic acid) were significantly associated with incident type 2 diabetes (hazard ratio per 1 SD difference, 1.15, 1.26 and 1.06, respectively). In contrast, measured odd-chain SFAs (pentadecanoic acid and heptadecanoic acid) were inversely associated with incident type 2 diabetes (HR per 1 SD difference, 0.79 and 0.67), as were longer-chain SFAs (arachidic acid, behenic acid, tricosanoic acid and lignoceric acid), with HRs ranging from 0.72 to 0.81. The results were "robust" across the countries and in a range of sensitivity analyses, the researchers say. Dr. Mozaffarian points out that when the investigators assessed dietary correlates, odd-chain SFAs were associated most strongly with dairy products, "as expected," while even-chain SFAs correlated more strongly with "drivers of de-novo lipogenesis, including alcohol, soft drinks, and potatoes, than with direct dietary sources such as meat, butter, or cheese." "Very-long-chain SFAs had weaker associations with diet than the other SFAs (although the strongest association was with nuts/seeds, which is one dietary source), which suggests that metabolic determinants could be especially important for plasma long-chain SFAs," he notes. Dr. Forouhi and colleagues say their findings emphasize "the importance of the recognition of subtypes of these fatty acids." The findings, Dr. Mozaffarian adds, "draw attention to the need for investigation of the intriguing and remarkably understudied very-long chain SFAs, the determinants (dietary and metabolic) and health effects of which remain largely unknown." In his view, "The consistent evidence for differing health effects of different SFAs, and their varying endogenous versus dietary determinants, remains under-recognised by many scientists, clinicians, media writers, and policy makers. Taken together with other advances in nutritional science, now is the time to redesign our process of setting dietary guidelines." SOURCE: bit.ly/1obDgeH and bit.ly/1obDgeH Lancet Diabetes Endocrinol 2014. Post Comment Private Reply Ignore Thread Top • Page Up • Full Thread • Page Down • Bottom/Latest Begin Trace Mode for Comment # 1.
#1. To: Tatarewicz (#0)
I say to hell with it. Enjoy those saturated fats while you can, because ISIS is going to kill us all anyway.
#2. To: Obnoxicated (#1)
Good point. At 67+, I fail to care.
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