Italian Prime Minister Matteo Renzi has lost a key referendum on constitutional reform, exit polls suggest. Polls for national broadcaster Rai and the La7 television channel both projected the "No" camp as winners by a margin of at least 54% to 46%.
Mr Renzi had staked his future on a "Yes" vote, vowing to resign if voters rejected his plans to reduce the role of the country's Senate and take back powers from regional authorities.
He is due to address the nation at around midnight local time (11pm UK time. 6 pm US CT).
Opposition parties were quick to call for Mr Renzi to go.
"Renzi is going to go and with him the powerful lobbies who were also defeated", Renato Brunetta, the parliamentary leader of former prime minister Silvio Berlusconi's centre-right Forza Italia party.