The median annual Paramedic salary in San Francisco, CA is $51,178, as of March 29, 2018, with a range usually between $45,953-$58,325 not including bonus and benefit information and other factors that impact base pay. Keep in mind that California has a very high state income tax and a high sales tax. And registering a car is outrageous. Craigslist lists rooms to share in SF starting at $1,400 a month. A 2 bedroom apt would be the minimum for a family. That is unaffordable to people making above the median wage.