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Health
See other Health Articles

Title: Secret to Longevity May Lie in Microbiome & Gut
Source: [None]
URL Source: [None]
Published: Jun 3, 2018
Author: staff
Post Date: 2018-06-03 09:45:47 by Tatarewicz
Keywords: None
Views: 138
Comments: 5

TEHRAN (FNA)- Scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies' longevity by 60 percent and protect them against chronic diseases associated with aging.

You are what you eat. Or so the saying goes. Science now tells us that we are what the bacteria living in our intestinal tract eat and this could have an influence on how well we age. Building on this, McGill University scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies' longevity by 60 % and protect them against chronic diseases associated with aging.

The study, published in Scientific Reports, adds to a growing body of evidence of the influence that gut bacteria can have on health. The researchers incorporated a symbiotic -- made of probiotics with a polyphenol-rich supplement -- into the diet of fruit flies.

The flies fed with the synbiotic lived up to 66 days old -- 26 days more than the ones without the supplement. They also showed reduced traits of aging, such as mounting insulin resistance, inflammation and oxidative stress.

"Probiotics dramatically change the architecture of the gut microbiota, not only in its composition but also in respect to how the foods that we eat are metabolized," says Satya Prakash, professor of biomedical engineering in McGill's Faculty of Medicine and senior author of the study. "This allows a single probiotic formulation to simultaneously act on several biochemical signaling pathways to elicit broad beneficial physiological effects, and explains why the single formulation we present in this paper has such a dramatic effect on so many different markers."

The fruit fly is remarkably similar to mammals with about 70 % similarity in terms of their biochemical pathways, making it a good indicator of what would happen in humans, adds Prakash.

"The effects in humans would likely not be as dramatic, but our results definitely suggest that a diet specifically incorporating Triphala along with these probiotics will promote a long and healthy life."

The authors also say that the findings can be explained by the "gut-brain axis," a bidirectional communication system between microorganisms residing in the gastrointestinal tract -- the microbiota -- and the brain. In the past few years, studies have shown the gut-brain axis to be involved in neuropathological changes and a variety of conditions such as irritable bowel syndrome, neurodegeneration and even depression. Few studies, however, have successfully designed gut microbiota-modulating therapeutics having effects as potent or broad as the formulation presented in the new study.

Learning from traditional medicine

The herbal supplement used in the study, Triphala, is a formulation made from amalaki, bibhitaki and haritaki, fruits used as medicinal plants in Ayurveda, a form of traditional Indian medicine.

Susan Westfall, a former PhD student at McGill and lead author of the study, says the idea of combining Triphala and probiotics comes from her long-standing interest in studying natural products derived from traditional Indian medicine and their impact on neurodegenerative diseases.

"At the onset of this study, we were hopeful that combining Triphala with probiotics would be at least a little better than their individual components in terms of physiological benefit, but we did not imagine how successful this formulation would be," says Westfall, who is now a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai in New York, USA.

The new study, which includes data filed in a US provisional patent through a company cofounded by the authors, has the potential to impact the field of the microbiome, probiotics and human health.

Considering the broad physiological effects of this formulation shown in the fruit fly, Prakash hopes their formulation could have interesting applications in a number of human disorders such as diabetes, obesity, neurodegeneration, chronic inflammation, depression, irritable bowel syndrome and even cancer.

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#1. To: Tatarewicz (#0) (Edited)

Secret to Longevity May Lie in Microbiome & Gut

Also, seeing that cancer was cured by Dr. Otto Warburg in Nazi Germany is of utmost importance.

And also there is no profit in a cure. Just treatment with expensive and ineffective chemotherapy and radiation.

Warburg discovered that cells need proper respiration, and when they do not get it they turn cancerous.

Warburg was awarded the Nobel Prize for Medicine but Hitler prevented him from picking it up because of the war. ;)

"When bad men combine, the good must associate; else they will fall, one by one." Edmund Burke

BTP Holdings  posted on  2018-06-03   9:54:44 ET  Reply   Trace   Private Reply  


#2. To: Tatarewicz (#0)

It's shortevity I'm interested in, so I'll do the opposite. Fruit flies may consider this a groovy world in which to extend your lifespan, but they've never heard of Joy Behar.

_____________________________________________________________

USA! USA! USA! Bringing you democracy, or else! there were strains of VD that were incurable, and they were first found in the Philippines and then transmitted to the Korean working girls via US military. The 'incurables' we were told were first taken back to a military hospital in the Philippines to quietly die. – 4um

NeoconsNailed  posted on  2018-06-03   21:48:22 ET  Reply   Trace   Private Reply  


#3. To: BTP Holdings (#1)

there is no profit in a cure

That's why we have to abandon the money-based economy and adopt one based on merit.

In a cyber age political and money systems constitute a progress-stifling redundancy. Much better to have teams of computer programmers catalog people's skills and talents, determine people's needs then mobilize trained personnel and resources to ensure everyone's basics of food, shelter, etc., are met, assigning merit points to those meeting goals successfully, allocating performance merit points for perks beyond basics. Neither politicians, government bureaucrats or the private sector can readily meet everyone's needs within a system based on an individual's whim to do something, on money availability and political"clowns" with smiling faces. Computers can be programmed to arrange for personnel training, make people/machines available to do whatever is needed domestically or abroad. Money is just a primitive bookkeeping system open to criminal activity; none working in it produce any wealth. Rather than have entertaining political clowns determine society's priorities and directions have head hunters recommend a talented board of directors the same way corporations do.

In health field we need lots of well-trained personnel guiding folks to better personal health and doing as little as possible in terms of physical/chemical intervention; basically on standby for emergencies, epidemics, engaged as much as possible in research.

Tatarewicz  posted on  2018-06-05   2:00:38 ET  Reply   Trace   Private Reply  


#4. To: Tatarewicz (#3)

I was reading a review from some guy who attended a concert in Chicago. He was complaining about how rude the staff (security) was there. I told him, "It's a free country. No one is forcing you to go there to see a concert. But, I worked that gig in the 80s and 90s. You had to deal with drunks and people who were high on some kind of dope. Even people who were just plain assholes. So you had to have a bad attitude with them and you couldn't take any shit from them either." ;)

"When bad men combine, the good must associate; else they will fall, one by one." Edmund Burke

BTP Holdings  posted on  2018-06-05   5:58:17 ET  Reply   Trace   Private Reply  


#5. To: BTP Holdings (#4)

A second compatriot, (since I mentioned it recently here) reports having a terrible time getting workers because they're dope fiends. He's a house painter, the other works in a car repair chain. Hate to say it but it leaves me wondering if there's any truth the the claim that the invaders are "doing the jobs Americans won't do".

_____________________________________________________________

USA! USA! USA! Bringing you democracy, or else! there were strains of VD that were incurable, and they were first found in the Philippines and then transmitted to the Korean working girls via US military. The 'incurables' we were told were first taken back to a military hospital in the Philippines to quietly die. – 4um

NeoconsNailed  posted on  2018-06-05   7:13:45 ET  Reply   Trace   Private Reply  


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