Physicians in Wuhan, China, the epicenter for COVID-19 coronavirus that is now infecting human populations around the globe, report a shortage of test kits for this infectious pathogen. But maybe doctors rather than test for a virus ought to be testing for a viral vulnerability factor – an unstable form of haptoglobin (HAPTO-G), genetically prevalent in Asian populations. What is haptoglobin? (hap-tow-glow-bin) This blood protein binds to hemoglobin, the red protein in red blood cells that carries both oxygen and iron. By virtue of its binding power, haptoglobin mops up hemoglobin and loose iron when red blood cells die off so as to limit the availability of potentially destructive unbound iron.
Out of three types of haptoglobin (HAPTO-G), one type doesn’t bind as well to hemoglobin, releases excess iron which then increases iron-induced oxidation (rusting), and increases oxidation (hardening) of cholesterol and degradation of vitamin C.