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World News See other World News Articles Title: CDC Expects 200k COVID-19 Deaths By October As Dreaded 'Second Wave' Arrives: Live Updates Summary: Moderna releases latest vaccine update Scott Gottlieb explains the problem with Texas' response Epidemiologists warn about threat of 'second wave' Mumbai hospitals overwhelmed Russia cases top 500k Latin America death toll tops 80k US projects nearly 200k COVID deaths by October LA County still seeing ~1,300 new cases a day as reopening continues * * * Update (0840ET): With Dow futures pointing to a 1,000-point drop at the open as the Fed's dismal economic projections and Powell's comment that the Fed "isn't even thinking about raising interest rates" weigh on risk appetite and the cyclical stocks that have driven the latest leg of the rally, Moderna has released its latest 'update' on its vaccine trials, which are being run in partnership with the NIH. According to the announcement, Moderna has "finalized its Stage 3 protocols", according to a brief press release. CAMBRIDGE, Mass.–(BUSINESS WIRE)–Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced progress on late-stage development of mRNA-1273, the Company’s mRNA vaccine candidate against COVID-19. Moderna has finalized the Phase 3 study protocol based on feedback from the U.S. Food and Drug Administration (FDA). The randomized, 1:1 placebo-controlled trial is expected to include approximately 30,000 participants enrolled in the U.S. and is expected to be conducted in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The trial’s primary endpoint will be the prevention of symptomatic COVID-19 disease; key secondary endpoints include prevention of severe COVID-19 disease (as defined by the need for hospitalization) and prevention of infection by SARS-CoV-2, the virus that causes COVID-19. The primary efficacy analysis will be an event-driven analysis based on the number of participants with symptomatic COVID-19 disease. Based on the results of the Phase 1 study, the 100 ¼g dose level was chosen as the optimal dose level to maximize the immune response while minimizing adverse reactions. Moderna has completed manufacture of vaccine required to start the Phase 3 study. The Company expects dosing in the Phase 3 study to begin in July. Meanwhile, one twitter user pointed at a pattern that we have noticed as well. Jim Cramer ✔ @jimcramer Jimmy Chill points out that hospitalizations are up. Interesting that a person named "Observations" is having trouble observing https://twitter.com/observations_b/status/1271053254613327873 … alannajoy @alannajoy Hasn't anyone else noticed over the past few months that whenever there's a pre-market or expected pullback in the market, there's COVID-19 vaccine/therapeutic research information released, even though mostly premature and unsubstantiated? Twice this morning with Dow down 700pts Update (0720ET): Former FDA Commissioner and perennial "Squawk Box" guest Scott Gottlieb offered some commentary about the situation in Texas, explaining that characterizing this as a 'second wave' might be misleading since 'they never really got over the first'. The fact that Texas hasn't traced the rising case numbers, which are overwhelmingly centered in the greater Houston area, to a specific source - like a meatpacking plant or something - worries Gottlieb, because that means the contact tracers in the state have failed at their basic mission: to find the source of any 'super-spreader' incidents quickly before they become 'super-duper spreaders'. Thanks for the comforting words, doc. * * * With futures pointing to a sharp drop at the open for the Dow, it appears investors are finally confronting signs of a second wave that have emerged both in the US, and around the world. As one scientist who appeared on CNBC's Worldwide Exchange program Thursday morning claimed, signs of a genuine second wave have emerged around the world, including in Sweden and Iran. Fortunately, we haven't seen a sharp move higher in mortality alongside the surge in cases - but that could follow. Across the northeast and Atlantic Coast, more states are lifting bans on outside graduation ceremonies, with Maryland Gov Larry Hogan announcing late Wednesday evening that he would allow outdoor graduation ceremonies in the state to move forward starting Friday. Bad news for all you 'influencers' out there: Both Coachella and Stagecoach, two of the largest music festivals held each year in Southern California, have been canceled. Organizers moved both events to October, but have now decided to forgo them until next year (but don't despair influencers, there will be many more protests to use as a backdrop for your selfies between now and the end of the year). Last night, we reported that Mumbai, India's wealthiest city and financial capital, had surpassed the total number of infections reported in Wuhan, the original epicenter of the virus. Mumbai is also India's entertainment capital, home to 'Bollywood', the Indian film industry. The city has reported more than 50k cases, nearly a fifth of India's total, and more than the Chinese city of Wuhan, ground zero for the pandemic. The broader Maharashtra state has now confirmed more cases than the whole of China. India has recorded more than 286,000 coronavirus cases, including at least 8,100 deaths, according to the Indian Ministry of Health and Family Welfare. Although Mumbai is India's wealthiest city, and its most international, public hospitals have been totally overwhelmed by the virus, with doctors collapsing from exhaustion and dehydration. "We expected that if infection took root, the health system would be overwhelmed," said Rajeev Sadanandan, Kerala's former health secretary and the chief executive of non-profit Health Systems Transformation Platform. "With the kind of population Mumbai has, there is no way that the infrastructure would have been enough." Russia crossed a grim milestone on Thursday when it reported another 8,779 confirmed cases of the virus on Thursday, bringing the total for the Russian Federation to 502,436, making Russia the third country to pass 500k cases after the US and Brazil. Another 174 deaths were recorded, bringing Russia's deaths to 6,532. However, some observers fear the true total in the country - for deaths and cases - is much higher, since not every patient who tests positive for COVID-19 and then dies is counted as a 'COVID-1 Earlier this week, Moscow's mayor lifted self-isolation restrictions and the city is expected to reopen by the end of the month. After the US topped 2 million confirmed cases last night, a set of COVID-19 projections maintained by the University of Washington has just been updated, and is now projecting 170k COVID-19 linked deaths in the US by Oct. 1, that would be a rise of nearly 80% by October. IHME, the institute that maintains the model, said it's based on data through June 6. "Large gatherings in some states due to lifting of social distancing restrictions, gatherings on national holidays, and public protests are reflected in the general trend toward increased mobility." In the US, more than 20 states are seeing a rise in the daily number of new cases, per the NYT. The flareup in Latin America and the Caribbean also reached a new milestone as deaths in the region surpassed 70k: Brazil, the worst-hit country in the region, has identified more than 772,000 cases, according to Johns Hopkins University. Peru and Mexico, which just reported a record daily surge in new cases, are also seeing uncontrolled spread. Mexican paramedics are responding to 911 calls at an alarming rate, as the coronavirus pandemic continues to ravage Mexico City. Quarantine measures have been extended in Chile, the health ministry said in a statement released Wednesday. Meanwhile, in LA, more businesses, including gyms and museums, are reopening, even as the county continues to report about 1,300 new cases per day. There are 67,064 confirmed coronavirus cases and 2,768 deaths in Los Angeles County as of Thursday morning. Post Comment Private Reply Ignore Thread
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