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Health See other Health Articles Title: sucralose More than 40 percent of Americans say they want to use less aspartame, sucralose, and saccharine, according to a recent survey. And to that 40 percent I have just two words: good call! Unfortunately, many people may be consuming an abundance of sucralose, believing it's a healthy sugar substitute. But a new study says no. This study, from Duke University, isn't the first warning that heavy intake of sucralose (better known by the brand name Splenda) may be linked to health problems. Several years ago an HSI member wrote to ask if sucralose was as bad as other artificial sweeteners. In response, HSI Panelist Allan Spreen, M.D., noted that any claim about sucralose being "natural," is naturally false. Dr. Spreen: "The stuff is patented and involves taking sugar molecules and treating them with (ulp) chlorine. "The argument is that the chlorine is not absorbed at all, so therefore the agent is harmless. There have since been reports of up to 30% being absorbed and symptoms being caused. I don't really know what percentage, if any, is absorbed (though I bet it's higher than zero). However, I don't trust the stuff, though it may have less after-taste than stevia." According to the sucralose "Final Rule" issued by the FDA, the body may absorb from 11 to 27 percent of ingested sucralose. But research from the Japanese Food Sanitation Council doesn't agree, estimating that as much as 40 percent is absorbed. How chlorine absorption from sucralose affects us isn't clear. But something in the sweetener appears to prompt stomach pains and gas pains the two primary complaints about sucralose. This new study may explain the indigestion discomfort, while also raising the possibility of greater harm. For 12 weeks, Duke researchers fed varying amounts of sucralose to rats. Fecal samples were examined weekly. Analysis showed that sucralose altered pH balance in the intestines and prompted weight gain. But two additional results were quite worrying: Good bacteria in the intestines were dramatically reduced by 50 percent! while P-glycoproteins were increased a condition that limits the absorption of oral drugs. According to James Turner, chairman of the consumer advocacy group Citizens for Health, just two slices of sucrose-sweetened cake and two cups of coffee with Splenda might be enough to affect P-glycoproteins and compromise drug absorption a potentially devastating situation for patients undergoing chemotherapy. Mr. Turner has called on the FDA to insist that Splenda products carry a warning label to caution patients on medications and those with gastrointestinal issues. Of course, more research will be needed to confirm these findings. But anyone following the Atkins diet should know that most of the Atkins snack and dessert products are sweetened with Splenda. In keeping with the Atkins diet, Splenda use avoids blood sugar spikes that lay the groundwork for type 2 diabetes a benefit that may come packaged with potential risks. Sources: "Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats" Journal of Toxicology and Environmental Health Part A, vol. 71, No. 21, January 2008, informaworld.com "Chairman of Citizens for Health Declares FDA Should Review Approval of Splenda" Citizens for Health press release, 9/22/08, globenewswire.com www.healthiertalk.com ">Click for Full Text!
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