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Title: Global variation in copy number in the human genome
Source:
Nature
URL Source: http://www.nature.com/nature/journa ... 44/n7118/full/nature05329.html
Published: Oct 30, 2006
Author: Richard Redon, et. al.
Post Date: 2009-01-30 14:25:36 by Prefrontal Vortex
Keywords: None
Views: 667
Comments: 23
Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these individuals was screened for CNV using two complementary technologies: single-nucleotide polymorphism (SNP) genotyping arrays, and clone-based comparative genomic hybridization. A total of 1,447 copy number variable regions (CNVRs), which can encompass overlapping or adjacent gains or losses, covering 360 megabases (12% of the genome) were identified in these populations. These CNVRs contained hundreds of genes, disease loci, functional elements and segmental duplications. Notably, the CNVRs encompassed more nucleotide content per genome than SNPs, underscoring the importance of CNV in genetic diversity and evolution. The data obtained delineate linkage disequilibrium patterns for many CNVs, and reveal marked variation in copy number among populations. We also demonstrate the utility of this resource for genetic disease studies.
Poster Comment: 12% CNV variation and 30% SNP variation If someone tells you "we're all the same", he's either willfully ignorant or a dishonest scumbag. Individuals may differ from each other in as many as 44% of their genes. The new research wiped out the widespread concept that all humans are genetically 99.9 % alike. Venter was one of the first to advocate this in 2000 after the completion of the first map of the human genome, a project in which he was also involved. But those works significantly underestimated genetic diversity because the whole was the result of DNA samples achieved from several individuals. The new genome, called "HuRef", shows more complex differences than previously detected single nucleotide polymorphisms (SNPs) (changes of just one nucleotide, the building molecular bricks of DNA), which determine simple mutations, once believed to be the main cause of differences in human traits and disease vulnerability. It seems that changes in the previously disregarded "junk DNA" are equally important. "This dispels the notion we had in 2000 and 2001 that we all have exactly the same genes in the human population. It would have been very disturbing if the range of characteristics that we see all came down to a few simple SNP variations," said Venter. Now it appears that individual genome can vary from individual to individual up to 44 % of genes. "This is a number that geneticists and biologists have been wondering about for 50 to 100 years," said co-author Stephen Scherer, a geneticist at The Hospital for Sick Children in Toronto.
Global variation in copy number in the human genome
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#1. To: Prefrontal Vortex (#0)
that is one of the things i have always said. people operate with unproven beliefs. there is actually no proof at all that every one of the inhabitants of the earth is human, they are hominids that appear to be human, but until they are tested, we really don't KNOW if they are. sounds silly, but it is the truth.
if a people will not prosecute officials who subvert and violate the constitution, then the constitution has no authority over officials. Gengis Gandhi, Troubled Genius
What makes a man - genes or soul (for lack of a better word)?
Law Enforcement Against Prohibition You think the people of this country exist to provide you with position. I think your position exists to provide those people with freedom.~~William Wallace ALAS, BABYLON
False choice; here's what makes a white man.
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
I wonder. here's what makes a white man. I know white men that can't even begin to measure up to that poem.
The genetics trap is just that, a trap. As codified law, the tribal, genetic code began where again?
Irrelevant. If you substitute "variation in souls" for "variation in genes", it's still Lewontin's goddamn Fallacy.
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
Attacking another's tribalism per se can in the end only backfire on my own tribe -- if I am sincere in my anti-tribalism. I would prefer to preserve both my tribe and my sincerity.
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
Another Jew wriggling in the gene trap. ; )
I'm down with that. It's a given. One's own family/tribe and integrity is, or should be, inviolate. My point is that genetic preference as political identification gets us right where the worst of the Jews are today. It's a trap.
I saw it more as his trap for objective, scientifically-minded whites. (Those for whom "God would never do that" doesn't cut it.)
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
There's always the inherent double-standard. It's why I've always avoided identifying my political activities with race/genetics. I see where it gets those that do it.
For one thing, mere whiteness is not an identity to rally around. As Bob says, the South is the only real nation in the States. White men once spoke of the British race, or the German race. Race alone does not make a nation, but nations are racial.
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
That's why when I use the word 'race', I tend towards Yockey's descriptions: "RACE, as has been shown, is not a unit of existence, but is an aspect of existence. Specifically it is the aspect of existence in which the relation of the human being to the great cosmic rhythms is revealed. It is thus the non-individual aspect of Life, whether it be the life of a plant, animal, or human being. The plant exhibits — at least, not to us — no consciousness, i.e., no tension with its environment. The plant has thus only race, so to speak, for it is totally submerged in the cosmic flow. The animal exhibits tension, consciousness, individuality. Man has in addition self-consciousness and the ability and necessity of living a higher life in the realm of symbols. All men have this, but the difference in degree between primitive man and Culture-man in this respect is so vast that it seems almost a difference in kind. It is the racial beat which informs primitive impulses, which informs action generally. Opposed to it is the illuminated part of the mind, the rootless reason, the intellect. The stronger these things are in relation to the racial plane, the more the existence bears an intellectual instead of a racial stamp. Each individual, as well as each higher organic unit, has these two aspects. Race impels toward self-preservation, continuance of the cycle of generations, increase of power. Intellect decides the meaning of the Life, and the aim, and this may, for various reasons, deny one or all of these fundamental urges. The celibacy of the priest and the sterility of the libertine both come from intellect, but one of them is an expression of High Culture, and the other is the denial of Culture, an expression of total degeneracy. Intellect may thus be in the service of Culture, or opposed to it. Race is, in the first instance — in its subjective sense — what a man feels. This influences, whether immediately or eventually, what he does. A man of race is not born to slavery. If his intellect counsel him to a temporary submission, rather than an heroic death, in the hope of future changes, it is a mere postponement of his breaking out. The man without race will submit permanently to any humiliation, any insult, any dishonor, so long as he is permitted to live. The continuance of breathing and digestion are Life to the man without race. To the man of race, Life itself represents no value, but only Life under the right conditions, affirmative Life, rich, expressive and growing. Heroism can be motivated from either side of the soul: the martyr dies for the Truth which he knows, the fighting man who dies with weapons in his hands rather than submit to his enemies dies for the honor that he feels. But the man who dies for something higher shows that he has race, regardless of his intellectualized motives. For Race is the faculty of being true to one's self. It is the placing of a beyond-value on one's own individual soul." I like that.
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
Exactly - genetics is the "creation myth" of the Secular Humanist crowd. Genetics speaks to the pattern of the human body not of the human spirit.
""I think the subject which will be of most importance politically is Mass Psychology...It's importance has been enormously increased by the growth of modern methods of propaganda...Although this science will be diligently studied, it will be rigidly confined to the governing class. The populace will not be allowed to know how its convictions were generated." Bertrand Russel, Eugenicist and Logician
Yockey was something special. That's why they killed him.
Well stated. I'm borrowing it.
Thank you for the complement and please feel free.
""I think the subject which will be of most importance politically is Mass Psychology...It's importance has been enormously increased by the growth of modern methods of propaganda...Although this science will be diligently studied, it will be rigidly confined to the governing class. The populace will not be allowed to know how its convictions were generated." Bertrand Russel, Eugenicist and Logician
Naughty Girl! I like it. :-)
""I think the subject which will be of most importance politically is Mass Psychology...It's importance has been enormously increased by the growth of modern methods of propaganda...Although this science will be diligently studied, it will be rigidly confined to the governing class. The populace will not be allowed to know how its convictions were generated." Bertrand Russel, Eugenicist and Logician
If all it takes is a pencil, I'm all set.
White Man's Burden: A shovel and a pencil!
The memory of the Heroic Age was eagerly seized by all who could take power, by fair means or foul, but that age could not be recaptured, and despite the temporary improvements... the racial material on which they had to work was of little value, and their efforts bore no fruit after their own demise.
#2. To: gengis gandhi, Prefrontal Vortex (#1)
#3. To: Prefrontal Vortex, REDPANTHER (#0)
Gorillas in the Midst PING!
"Corporation: An entity created for the legal protection of its human parasites, whose sole purpose is profit and self-perpetuation." ~~ IndieTx
#4. To: bluegrass (#2)
#5. To: Prefrontal Vortex (#4)
False choice
#6. To: Prefrontal Vortex (#4)
#7. To: bluegrass (#5)
I know white men that can't even begin to measure up to that poem.
#8. To: bluegrass (#6)
As codified law, the tribal, genetic code began where again?
#9. To: Prefrontal Vortex (#7)
If you substitute "variation in souls" for "variation in genes", it's still Lewontin's goddamn Fallacy.
#10. To: Prefrontal Vortex (#8)
I would prefer to preserve both my tribe and my sincerity.
#11. To: bluegrass (#9)
Another Jew wriggling in the gene trap. ; )
#12. To: Prefrontal Vortex (#11)
I saw it more as his trap for objective, scientifically-minded whites.
#13. To: bluegrass (#12)
#14. To: Prefrontal Vortex (#13)
#15. To: bluegrass (#14)
#16. To: bluegrass (#6)
The genetics trap is just that, a trap. As codified law, the tribal, genetic code began where again?
#17. To: Prefrontal Vortex (#15)
#18. To: Original_Intent (#16)
genetics is the "creation myth" of the Secular Humanist crowd.
#19. To: Prefrontal Vortex, bluegrass (#4)
here's what makes a white man.
Meet the new boss, same as the old boss — The Who
#20. To: bluegrass (#18)
#21. To: farmfriend (#19)
#22. To: farmfriend (#19)
#23. To: farmfriend (#19)
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