US President Donald Trump’s course correction of his foreign policy team is shifting into overdrive with Iran hawks and staunchly pro-Israel officials axed, including one who drew the ire of "America First" Trump allies.

The officials being dismissed are all those with previous track records opposing what are shaping up to be Trump’s most significant Middle East endeavours: swiftly lifting sanctions on Syria and negotiating a nuclear deal with Iran.

The reshuffle comes after Trump’s landmark visit to Saudi Arabia, the UAE and Qatar last month. In a speech in Riyadh, Trump tore into "interventionists" and American "nation builders".